Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/7486
Title: Correlation of O6-Methylguanine DNA methyltransferase promoter methylation and clinicopathological parameters in bladder cancer
Authors: Çetin, Gökhan Ozan
Caner, Vildan
Türk, Nilay Şen
Okur, V.
Can, O.
Eskicorapci, S.
Tuncay, L.
Keywords: Bladder cancer
Methylation
O6-Methylguanine DNA methyltransferase
Urothelial carcinoma
methylated DNA protein cysteine methyltransferase
adult
aged
Article
bladder cancer
cancer grading
cancer incidence
cancer patient
cancer prognosis
cell proliferation
clinical feature
DNA methylation
female
histopathology
human
major clinical study
male
promoter region
real time polymerase chain reaction
tissue fixation
transitional cell carcinoma
tumor cell
Publisher: Gene Therapy and Molecular Biology
Abstract: Bladder cancer is the one of the most common cancers worldwide and O6-Methylguanine DNA Methyltransferase (MGMT) promoter methylation might be contributing to clinicopathological features of the disease. We analyzed formalin-fixed, paraffin-embedded bladder tissue samples from 101 patients with urothelial carcinoma. All samples were analyzed by real-time methylation-specific PCR. MGMT promoter methylation was detected in 15 (14.9%) of the samples and was not significantly different between any of the groups, although the number of high grade tumors with MGMT promoter methylation was twice the number of low grade tumors. Methylation of MGMT in high grade tumors might play a role in aggressive proliferation of the tumor cells and a poor prognosis.
URI: https://hdl.handle.net/11499/7486
ISSN: 1529-9120
Appears in Collections:Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
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