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https://hdl.handle.net/11499/7716
Title: | Apelin-induced hemorheological alterations in DOCA-salt hypertensive rats | Authors: | Kursunluoglu-Akcilar, R. Kılıç-Toprak, Emine Kılıç-Erkek, Özgen Turgut, S. Bor-Küçükatay, Melek |
Keywords: | Aggregation Apelin DOCA-salt hypertensive rats Erythrocyte deformability apelin deoxycorticosterone sodium chloride Apln protein, rat deoxycorticosterone acetate signal peptide analyzer animal cell animal experiment animal model article blood pressure monitoring blood rheology blood sampling controlled study deoxycorticosterone-salt induced hypertension erythrocyte aggregation erythrocyte deformability male nonhuman rat shear stress systolic blood pressure animal blood chemically induced disease model drug effects hypertension randomization Wistar rat Animals Desoxycorticosterone Acetate Disease Models, Animal Erythrocyte Aggregation Erythrocyte Deformability Hemorheology Hypertension Intercellular Signaling Peptides and Proteins Male Random Allocation Rats Rats, Wistar |
Publisher: | IOS Press | Abstract: | Apelin is a hypotensive peptide. Red blood cell (RBC) deformability and aggregation were previously demonstrated to be altered in various hypertension (HT) models. In the present study, we investigated possible alterations in RBC deformability and aggregation in response to apelin in DOCA-salt hypertensive rats. Rats were randomly divided into 4 groups: Control (C), Hypertension (HT), Apelin, and Apelin + Hypertension (Apelin + HT). HT was induced by injection of DOCA-salt (25 mg/kg, s.c.) twice weekly for 4 weeks, whereas apelin was administered (200 µg/kg i.p.) for 17 days. RBC deformability and aggregation were determined using an ektacytometer. Blood pressure was monitored using a tail cuff system. Systolic blood pressure was decreased in the Apelin and Apelin + HT groups and increased in the HT group. RBC deformability was not significantly altered in the HT group. Apelin administration induced a statistically significant increase in RBC deformability in control animals, whereas erythrocytic deformability in the Apelin + HT group was decreased compared to the Apelin group. RBC aggregation of hypertensive animals was reduced compared to controls. Apelin administration induced increased RBC aggregation in hypertensive rats. Our results showed favorable effects of apelin on RBC deformability in control animals, but not in hypertensive rats. © 2014 - IOS Press. | URI: | https://hdl.handle.net/11499/7716 https://doi.org/10.3233/CH-121649 |
ISSN: | 1386-0291 |
Appears in Collections: | Denizli Sağlık Hizmetleri Meslek Yüksekokulu Koleksiyonu PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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