Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/8253
Title: Resistin and leptin levels in acromegaly: Lack of correlation With echocardiographic findings
Authors: Gürbulak, Sabriye
Yaylalı, Güzin Fidan
Yerlikaya, Emrah
Akın, Fulya
Topsakal, Şenay
Tanrıverdi, Halil
Akdağ, Beyza
Keywords: Acromegaly
Leptin
Resistin
glucose
growth hormone
insulin
leptin
resistin
somatomedin binding protein 3
somatomedin C
acromegaly
adult
article
blood flow velocity
body mass
cardiovascular parameters
clinical article
controlled study
disease association
echocardiography
female
glucose blood level
heart function
heart left ventricle ejection time
heart left ventricle endsystolic volume
heart left ventricle mass
heart ventricle hypertrophy
heart ventricle wall
homeostasis
human
insulin blood level
insulin resistance
interventricular septum thickness
left ventricular diastolic dysfunction
left ventricular systolic dysfunction
male
peak early mitral inflow velocity peak late mitral inflow velocity ratio
protein blood level
Publisher: BMJ Publishing Group
Abstract: Purpose: To find out how resistin and leptin levels were affected in patients with acromegaly and whether there is a relation between resistin levels and cardiac parameters. We also aimed to investigate whether resistin and leptin may be a link between insulin resistance and cardiac functions as well as these affected cardiac functions in the patients with acromegaly. Methods: We included 30 subjects (15 men and 15 women) who had a diagnosis of acromegaly and 30 healthy (10 men and 20 women) subjects. Serum glucose, insulin, growth hormone, insulinlike growth factor 1 (IGF-1), resistin, and leptin levels were obtained, and insulin resistance of subjects were calculated. Echocardiographic studies of the subjects were performed. Results: Resistin levels of the patientswith acromegaly were found lower than controls. This difference was statistically significant (P = 0.001). Leptin levels were lower in the patients with acromegaly than in the controls, but this difference was not statistically significant. Resistin and leptin levels were not correlated with growth hormone, IGF-1, and with insulinlike growth factor binding protein 3 levels. Homeostasis model assessment of insulin resistance was positively correlated with resistin levels. (P = 0.03; r = 0.531) but not correlated with leptin levels. There was a positive correlation between body mass index and leptin levels in the patients with acromegaly (P = 0.007; r = 0.482). Interventricular septum thickness, posterior wall thickness, left ventricle mass index, peak early mitral inflow velocity-peak late mitral inflow velocity ratio, deceleration time, ejection time, isovolumetric relaxation time, velocity propagation, and left ventricular end-systolic volume values were significantly greater in the patients with acromegaly. Leptin levels in the acromegalic patients were not correlated with any of them. Conclusions: We found biventricular hypertrophy and impairment of diastolic and systolic function in the patients with acromegaly. We conclude that changes in resistin and leptin levels are unlikely to account for the insulin resistance of acromegaly. They do not also seem to be contributing factors of cardiovascular changes in patients with acromegaly. Copyright © 2013 by The American Federation for Medical Research.
URI: https://hdl.handle.net/11499/8253
https://doi.org/10.2310/JIM.0b013e3182823390
ISSN: 1708-8267
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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