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Title: | Resistin and leptin levels in acromegaly: Lack of correlation With echocardiographic findings | Authors: | Gürbulak, Sabriye Yaylalı, Güzin Fidan Yerlikaya, Emrah Akın, Fulya Topsakal, Şenay Tanrıverdi, Halil Akdağ, Beyza |
Keywords: | Acromegaly Leptin Resistin glucose growth hormone insulin leptin resistin somatomedin binding protein 3 somatomedin C acromegaly adult article blood flow velocity body mass cardiovascular parameters clinical article controlled study disease association echocardiography female glucose blood level heart function heart left ventricle ejection time heart left ventricle endsystolic volume heart left ventricle mass heart ventricle hypertrophy heart ventricle wall homeostasis human insulin blood level insulin resistance interventricular septum thickness left ventricular diastolic dysfunction left ventricular systolic dysfunction male peak early mitral inflow velocity peak late mitral inflow velocity ratio protein blood level |
Publisher: | BMJ Publishing Group | Abstract: | Purpose: To find out how resistin and leptin levels were affected in patients with acromegaly and whether there is a relation between resistin levels and cardiac parameters. We also aimed to investigate whether resistin and leptin may be a link between insulin resistance and cardiac functions as well as these affected cardiac functions in the patients with acromegaly. Methods: We included 30 subjects (15 men and 15 women) who had a diagnosis of acromegaly and 30 healthy (10 men and 20 women) subjects. Serum glucose, insulin, growth hormone, insulinlike growth factor 1 (IGF-1), resistin, and leptin levels were obtained, and insulin resistance of subjects were calculated. Echocardiographic studies of the subjects were performed. Results: Resistin levels of the patientswith acromegaly were found lower than controls. This difference was statistically significant (P = 0.001). Leptin levels were lower in the patients with acromegaly than in the controls, but this difference was not statistically significant. Resistin and leptin levels were not correlated with growth hormone, IGF-1, and with insulinlike growth factor binding protein 3 levels. Homeostasis model assessment of insulin resistance was positively correlated with resistin levels. (P = 0.03; r = 0.531) but not correlated with leptin levels. There was a positive correlation between body mass index and leptin levels in the patients with acromegaly (P = 0.007; r = 0.482). Interventricular septum thickness, posterior wall thickness, left ventricle mass index, peak early mitral inflow velocity-peak late mitral inflow velocity ratio, deceleration time, ejection time, isovolumetric relaxation time, velocity propagation, and left ventricular end-systolic volume values were significantly greater in the patients with acromegaly. Leptin levels in the acromegalic patients were not correlated with any of them. Conclusions: We found biventricular hypertrophy and impairment of diastolic and systolic function in the patients with acromegaly. We conclude that changes in resistin and leptin levels are unlikely to account for the insulin resistance of acromegaly. They do not also seem to be contributing factors of cardiovascular changes in patients with acromegaly. Copyright © 2013 by The American Federation for Medical Research. | URI: | https://hdl.handle.net/11499/8253 https://doi.org/10.2310/JIM.0b013e3182823390 |
ISSN: | 1708-8267 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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