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https://hdl.handle.net/11499/8499| Title: | Orexins cause epileptic activity | Authors: | Erken, H.A. Erken, G. Gen, O. Kortunay, Selim Ahiner, M. Turgut, Günfer Turgut, Sebahat |
Keywords: | EEG Epilepsy Hypocretin Orexin Power spectrum Seizure orexin sodium chloride anesthesia animal experiment animal model article brain cortex controlled study electroencephalogram epileptic state male nonhuman priority journal rat seizure tonic clonic seizure Animals Disease Models, Animal Electroencephalography Injections, Intraventricular Intracellular Signaling Peptides and Proteins Male Neuropeptides Neurotransmitter Agents Rats Rats, Wistar Rattus |
Abstract: | Orexins have been implicated in the regulation of sleep-wake cycle, energy homeostasis, drinking behavior, analgesia, attention, learning and memory but their effects on epileptic activity are controversial. We investigated whether intracortical injections of orexin A (100 pmol) and B (100 pmol) cause epileptic activity in rats. We observed epileptic seizure findings on these two groups rats. Orexin A and B also significantly increased total EEG power spectrum. Our findings indicate that orexins cause epileptic activity. © 2012 Elsevier Inc. | URI: | https://hdl.handle.net/11499/8499 https://doi.org/10.1016/j.peptides.2012.06.012 |
ISBN: | 01969781 (ISSN) |
| Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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