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https://hdl.handle.net/11499/8540
Title: | Insulin-like growth factor I (Igf-1) gene polymorphism in patients with non-metastatic breast cancer | Authors: | Yaren, Arzu Turgut, Sebahat Ayada, Ceylan Akcılar, Raziye Değirmencioğlu, Serkan Gököz Doğu, Gamze |
Keywords: | Breast cancer Gene polymorphism Insulin-like growth factor Prognosis antineoplastic agent DNA insulin like growth factor 1 protein somatomedin unclassified drug adjuvant therapy adult article axillary lymph node breast cancer cancer adjuvant therapy cancer radiotherapy cancer recurrence cancer survival clinical feature DNA polymorphism female genetic analysis human lymph node dissection major clinical study mastectomy neoplasm overall survival partial mastectomy priority journal Adult Aged Aged, 80 and over Breast Neoplasms Disease-Free Survival Female Humans Insulin-Like Growth Factor I Middle Aged Neoplasm Recurrence, Local Polymorphism, Genetic |
Abstract: | We aimed to assess the association between IGF-I gene (CA repeats) polymorphism in breast cancer patients and their clinicopathological features, as well as disease recurrence and survival. Seventy-six non-metastatic breast cancer patients were enrolled in the present study. The IGF-I (CA) repeats were studied with polymerase chain reaction by using proper primers belonging to these gene areas from DNA samples. Results show that the non 19- non 19 homozygote were more common in patients without lymph node involvement (p = 0.04), with low histological grade (p = 0.04), with positive hormone receptor status (p = 0.01), and in patients without recurrence (p = 0.06). These results suggest that the non 19-non 19 carriers have some favorable prognostic factors, and IGF-I gene polymorphism (CA repeats) may affect disease recurrence and overall survival. © 2012 Elsevier B.V. | URI: | https://hdl.handle.net/11499/8540 https://doi.org/10.1016/j.gene.2012.04.078 |
ISSN: | 0378-1119 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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