Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/8546
Title: Alteration of drug metabolizing enzymes in sulphite oxidase deficiency
Authors: Tutuncu, Begüm
Küçükatay, Vural
Arslan, Şevki
Şahin, Barbaros
Semiz, Aslı
Şen, Alaattin
Keywords: Cytochrome P450s
Drug metabolizing enzymes
Rat
Sulphite oxidase deficiency
Sulphite sensitivity
aminopyrine n demethylase
aniline 4 hydroxylase
aromatase
caffeine n demethylase
cytochrome b5 reductase
dimethylnitrosamine demethylase
drinking water
drug metabolizing enzyme
erythromycin n demethylase
ethoxyresorufin deethylase
glutathione transferase
molybdenum
penthoxyresorufin o deethylase
sulfite oxidase
tungsten
unclassified drug
animal experiment
animal model
animal tissue
article
controlled study
diet
enzyme activity
enzyme deficiency
male
nonhuman
rat
xenobiotic metabolism
Rattus
Abstract: The aim of this study was to investigate the possible effects of sulphite oxidase (SOX, E.C. 1.8.3.1) deficiency on xenobiotic metabolism. For this purpose, SOX deficiency was produced in rats by the administration of a low molybdenum diet with concurrent addition of 200 ppm tungsten to their drinking water. First, hepatic SOX activity in deficient groups was measured to confirm SOX deficiency. Then, aminopyrine N-demethylase, aniline 4-hydroxy-lase, aromatase, caffeine N-demethylase, cytochrome b5 reductase, erythromycin N-demethylase, ethoxyresorufin O-deethylase, glutathione S-transferase, N-nitrosodimethylamine N-demethylase and penthoxyresorufin O-deethylase activities were determined to follow changes in the activity of drug metabolizing enzymes in SOX-deficient rats. Our results clearly demonstrated that SOX deficiency significantly elevated A4H, caffeine N-demethylase, erythromycin N-demethylase and N-nitrosodimethylamine N-demethylase activities while decreasing ethoxyresorufin O-deethylase and aromatase activities. These alterations in drug metabolizing enzymes can contribute to the varying susceptibility and response of sulphite-sensitive individuals to different drugs and/or therapeutics used for treatments. ©2012 JCBN.
URI: https://hdl.handle.net/11499/8546
https://doi.org/10.3164/jcbn.11-79
ISSN: 0912-0009
Appears in Collections:Fen-Edebiyat Fakültesi Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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