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https://hdl.handle.net/11499/8546
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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Tutuncu, Begüm | - |
dc.contributor.author | Küçükatay, Vural | - |
dc.contributor.author | Arslan, Şevki | - |
dc.contributor.author | Şahin, Barbaros | - |
dc.contributor.author | Semiz, Aslı | - |
dc.contributor.author | Şen, Alaattin | - |
dc.date.accessioned | 2019-08-16T12:42:15Z | |
dc.date.available | 2019-08-16T12:42:15Z | |
dc.date.issued | 2012 | - |
dc.identifier.issn | 0912-0009 | - |
dc.identifier.uri | https://hdl.handle.net/11499/8546 | - |
dc.identifier.uri | https://doi.org/10.3164/jcbn.11-79 | - |
dc.description.abstract | The aim of this study was to investigate the possible effects of sulphite oxidase (SOX, E.C. 1.8.3.1) deficiency on xenobiotic metabolism. For this purpose, SOX deficiency was produced in rats by the administration of a low molybdenum diet with concurrent addition of 200 ppm tungsten to their drinking water. First, hepatic SOX activity in deficient groups was measured to confirm SOX deficiency. Then, aminopyrine N-demethylase, aniline 4-hydroxy-lase, aromatase, caffeine N-demethylase, cytochrome b5 reductase, erythromycin N-demethylase, ethoxyresorufin O-deethylase, glutathione S-transferase, N-nitrosodimethylamine N-demethylase and penthoxyresorufin O-deethylase activities were determined to follow changes in the activity of drug metabolizing enzymes in SOX-deficient rats. Our results clearly demonstrated that SOX deficiency significantly elevated A4H, caffeine N-demethylase, erythromycin N-demethylase and N-nitrosodimethylamine N-demethylase activities while decreasing ethoxyresorufin O-deethylase and aromatase activities. These alterations in drug metabolizing enzymes can contribute to the varying susceptibility and response of sulphite-sensitive individuals to different drugs and/or therapeutics used for treatments. ©2012 JCBN. | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | Journal of Clinical Biochemistry and Nutrition | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Cytochrome P450s | en_US |
dc.subject | Drug metabolizing enzymes | en_US |
dc.subject | Rat | en_US |
dc.subject | Sulphite oxidase deficiency | en_US |
dc.subject | Sulphite sensitivity | en_US |
dc.subject | aminopyrine n demethylase | en_US |
dc.subject | aniline 4 hydroxylase | en_US |
dc.subject | aromatase | en_US |
dc.subject | caffeine n demethylase | en_US |
dc.subject | cytochrome b5 reductase | en_US |
dc.subject | dimethylnitrosamine demethylase | en_US |
dc.subject | drinking water | en_US |
dc.subject | drug metabolizing enzyme | en_US |
dc.subject | erythromycin n demethylase | en_US |
dc.subject | ethoxyresorufin deethylase | en_US |
dc.subject | glutathione transferase | en_US |
dc.subject | molybdenum | en_US |
dc.subject | penthoxyresorufin o deethylase | en_US |
dc.subject | sulfite oxidase | en_US |
dc.subject | tungsten | en_US |
dc.subject | unclassified drug | en_US |
dc.subject | animal experiment | en_US |
dc.subject | animal model | en_US |
dc.subject | animal tissue | en_US |
dc.subject | article | en_US |
dc.subject | controlled study | en_US |
dc.subject | diet | en_US |
dc.subject | enzyme activity | en_US |
dc.subject | enzyme deficiency | en_US |
dc.subject | male | en_US |
dc.subject | nonhuman | en_US |
dc.subject | rat | en_US |
dc.subject | xenobiotic metabolism | en_US |
dc.subject | Rattus | en_US |
dc.title | Alteration of drug metabolizing enzymes in sulphite oxidase deficiency | en_US |
dc.type | Article | en_US |
dc.identifier.volume | 51 | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.startpage | 50 | |
dc.identifier.startpage | 50 | en_US |
dc.identifier.endpage | 54 | en_US |
dc.authorid | 0000-0001-8952-5070 | - |
dc.identifier.doi | 10.3164/jcbn.11-79 | - |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.pmid | 22798713 | en_US |
dc.identifier.scopus | 2-s2.0-84863462047 | en_US |
dc.identifier.wos | WOS:000306387800009 | en_US |
dc.identifier.scopusquality | Q2 | - |
dc.owner | Pamukkale University | - |
item.grantfulltext | open | - |
item.openairetype | Article | - |
item.languageiso639-1 | en | - |
item.fulltext | With Fulltext | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.author.dept | 14.03. Basic Medical Sciences | - |
crisitem.author.dept | 17.02. Biology | - |
crisitem.author.dept | 01.01. Experimental Surgical Application and Research Center | - |
crisitem.author.dept | 20.03. Biomedical Engineering | - |
crisitem.author.dept | 17.02. Biology | - |
Appears in Collections: | Fen-Edebiyat Fakültesi Koleksiyonu PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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Alteration of drug metabolizing enzymes in sulphite oxidase deficiency.pdf | 342.67 kB | Adobe PDF | View/Open |
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