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Title: | Alteration of drug metabolizing enzymes in sulphite oxidase deficiency | Authors: | Tutuncu, Begüm Küçükatay, Vural Arslan, Şevki Şahin, Barbaros Semiz, Aslı Şen, Alaattin |
Keywords: | Cytochrome P450s Drug metabolizing enzymes Rat Sulphite oxidase deficiency Sulphite sensitivity aminopyrine n demethylase aniline 4 hydroxylase aromatase caffeine n demethylase cytochrome b5 reductase dimethylnitrosamine demethylase drinking water drug metabolizing enzyme erythromycin n demethylase ethoxyresorufin deethylase glutathione transferase molybdenum penthoxyresorufin o deethylase sulfite oxidase tungsten unclassified drug animal experiment animal model animal tissue article controlled study diet enzyme activity enzyme deficiency male nonhuman rat xenobiotic metabolism Rattus |
Abstract: | The aim of this study was to investigate the possible effects of sulphite oxidase (SOX, E.C. 1.8.3.1) deficiency on xenobiotic metabolism. For this purpose, SOX deficiency was produced in rats by the administration of a low molybdenum diet with concurrent addition of 200 ppm tungsten to their drinking water. First, hepatic SOX activity in deficient groups was measured to confirm SOX deficiency. Then, aminopyrine N-demethylase, aniline 4-hydroxy-lase, aromatase, caffeine N-demethylase, cytochrome b5 reductase, erythromycin N-demethylase, ethoxyresorufin O-deethylase, glutathione S-transferase, N-nitrosodimethylamine N-demethylase and penthoxyresorufin O-deethylase activities were determined to follow changes in the activity of drug metabolizing enzymes in SOX-deficient rats. Our results clearly demonstrated that SOX deficiency significantly elevated A4H, caffeine N-demethylase, erythromycin N-demethylase and N-nitrosodimethylamine N-demethylase activities while decreasing ethoxyresorufin O-deethylase and aromatase activities. These alterations in drug metabolizing enzymes can contribute to the varying susceptibility and response of sulphite-sensitive individuals to different drugs and/or therapeutics used for treatments. ©2012 JCBN. | URI: | https://hdl.handle.net/11499/8546 https://doi.org/10.3164/jcbn.11-79 |
ISSN: | 0912-0009 |
Appears in Collections: | Fen-Edebiyat Fakültesi Koleksiyonu PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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