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https://hdl.handle.net/11499/8744
Title: | Aluminium sulphate exposure increases oxidative stress and suppresses brain development in ross broiler chicks | Authors: | Oguz, Emin Oğuzhan Enli, Yaşar Şahin, Barbaros Gönen, Cafer Turgut, Günfer |
Keywords: | Aluminium Brain development Cavalieri brain volume estimation Glutathione Malondialdehyde Oxidative stress aluminum sulfate glutathione malonaldehyde article brain development brain growth chick controlled study egg embryo development incubation time lipid peroxidation nerve cell degeneration nonhuman oxidative stress |
Publisher: | International Scientific Literature Inc. | Abstract: | Background: Aluminium (Al) is known to have neurotoxic effects that can result in oxidative damage to a range of cellular biomolecules. These effects appear to be of significance in the developmental stages of the brain. We therefore investigated the oxidative and histopathological damage induced by Al during growth and development of the chick brain. Material/Methods: We used a chick embryonic development model, with Al treatment of 500 µg Al sulphate in 0.1 ml saline injected into the egg air chambers at the beginning of their incubation period. The effects on chick-brain growth and development were then assessed at term (day 21). Determination of malondialdehyde and glutathione levels were used as relevant biological measures for increased oxidative stress in terms of lipid peroxidation and biochemical oxidative damage, respectively. Furthermore, we also monitored neuronal degeneration as estimated stereologically using the Cavalieri brain volume estimation tool. Results: This Al treatment showed significantly increased MDA levels and decreased GSH levels, as indicators of increased biochemical oxidative damage. This was accompanied by significantly decreased brain volume, as a measure of neuronal degeneration during brain development in this chick embryonic development model. Conclusions: Exposure to Al during chick embryonic development results in increased oxidative stress in the brain that is accompanied by neuronal degeneration. © Med Sci Monit, 2012. | URI: | https://hdl.handle.net/11499/8744 https://doi.org/10.12659/MSM.882515 |
ISSN: | 1234-1010 |
Appears in Collections: | Acıpayam Meslek Yüksekokulu Koleksiyonu PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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