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https://hdl.handle.net/11499/9130
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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ceylan, B. | - |
dc.contributor.author | Arslan, F. | - |
dc.contributor.author | Sipahi, O.R. | - |
dc.contributor.author | Sunbul, M. | - |
dc.contributor.author | Ormen, B. | - |
dc.contributor.author | Hakyemez, İ.N. | - |
dc.contributor.author | Turunc, T. | - |
dc.date.accessioned | 2019-08-16T12:58:29Z | |
dc.date.available | 2019-08-16T12:58:29Z | |
dc.date.issued | 2017 | - |
dc.identifier.issn | 0303-8467 | - |
dc.identifier.uri | https://hdl.handle.net/11499/9130 | - |
dc.identifier.uri | https://doi.org/10.1016/j.clineuro.2016.12.006 | - |
dc.description.abstract | Aim To examine the variables associated with mortality in patients with Acinetobacter baumannii-related central nervous system infections treated with intrathecal colistin. Materials and methods This multi-centre retrospective case control study included patients from 11 centres in Turkey, as well as cases found during a literature review. Only patients with CNS infections caused by multidrug-resistant or extensively drug-resistant Acinetobacter baumannii treated with intrathecal colistin were included in this study. The variables associated with mortality were determined by dividing the patients into groups who died or survived during hospitalisation, and who died or survived from Acinetobacter meningitis. Results Among the 77 cases enrolled in the study, 35 were found through a literature review and 42 were cases from our centres. Forty-four cases (57.1%) were male and the median age was 48 years (range: 20–78 years). Thirty-seven patients (48%) died during hospitalisation. The variables associated with increased all-cause mortality during hospitalisation included old age (odds ratio, 1.035; 95% confidence interval (CI), 1.004–1.067; p = 0.026) and failure to provide cerebrospinal fluid sterilisation (odds ratio, 0.264; 95% confidence interval, 0.097–0.724; p = 0.01). There is a trend (P = 0.062) towards higher mortality with using of meropenem during meningitis treatment. Fifteen cases (19%) died from meningitis. There were no significant predictors of meningitis-related mortality. Conclusions The mortality rate for central nervous system infections caused by multidrug-resistant or extensively drug-resistant Acinetobacter baumannii is high. Old age and failure to provide CSF sterilisation are associated with increased mortality during hospitalisation. © 2016 | en_US |
dc.language.iso | en | en_US |
dc.publisher | Elsevier B.V. | en_US |
dc.relation.ispartof | Clinical Neurology and Neurosurgery | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Acinetobacter baumannii | en_US |
dc.subject | Colistin | en_US |
dc.subject | Intratechal | en_US |
dc.subject | Meningitis | en_US |
dc.subject | amikacin | en_US |
dc.subject | cefazolin | en_US |
dc.subject | cefepime | en_US |
dc.subject | ceftazidime | en_US |
dc.subject | ceftriaxone | en_US |
dc.subject | cefuroxime | en_US |
dc.subject | ciprofloxacin | en_US |
dc.subject | colistin | en_US |
dc.subject | gentamicin | en_US |
dc.subject | imipenem | en_US |
dc.subject | levofloxacin | en_US |
dc.subject | linezolid | en_US |
dc.subject | meropenem | en_US |
dc.subject | piperacillin plus tazobactam | en_US |
dc.subject | rifampicin | en_US |
dc.subject | sulbactam | en_US |
dc.subject | teicoplanin | en_US |
dc.subject | tigecycline | en_US |
dc.subject | vancomycin | en_US |
dc.subject | antiinfective agent | en_US |
dc.subject | thienamycin derivative | en_US |
dc.subject | Acinetobacter infection | en_US |
dc.subject | adult | en_US |
dc.subject | aged | en_US |
dc.subject | antibiotic therapy | en_US |
dc.subject | Article | en_US |
dc.subject | bacterial meningitis | en_US |
dc.subject | brain ventriculitis | en_US |
dc.subject | case control study | en_US |
dc.subject | central nervous system infection | en_US |
dc.subject | cerebrospinal fluid | en_US |
dc.subject | disease association | en_US |
dc.subject | female | en_US |
dc.subject | human | en_US |
dc.subject | major clinical study | en_US |
dc.subject | male | en_US |
dc.subject | middle aged | en_US |
dc.subject | mortality | en_US |
dc.subject | multicenter study | en_US |
dc.subject | nonhuman | en_US |
dc.subject | retrospective study | en_US |
dc.subject | young adult | en_US |
dc.subject | Acinetobacter Infections | en_US |
dc.subject | Cerebral Ventriculitis | en_US |
dc.subject | clinical trial | en_US |
dc.subject | intraspinal drug administration | en_US |
dc.subject | Meningitis, Bacterial | en_US |
dc.subject | outcome assessment | en_US |
dc.subject | pathogenicity | en_US |
dc.subject | Adult | en_US |
dc.subject | Aged | en_US |
dc.subject | Anti-Bacterial Agents | en_US |
dc.subject | Case-Control Studies | en_US |
dc.subject | Female | en_US |
dc.subject | Humans | en_US |
dc.subject | Injections, Spinal | en_US |
dc.subject | Male | en_US |
dc.subject | Middle Aged | en_US |
dc.subject | Outcome Assessment (Health Care) | en_US |
dc.subject | Retrospective Studies | en_US |
dc.subject | Thienamycins | en_US |
dc.subject | Young Adult | en_US |
dc.title | Variables determining mortality in patients with Acinetobacter baumannii meningitis/ventriculitis treated with intrathecal colistin | en_US |
dc.type | Article | en_US |
dc.identifier.volume | 153 | en_US |
dc.identifier.startpage | 43 | |
dc.identifier.startpage | 43 | en_US |
dc.identifier.endpage | 49 | en_US |
dc.identifier.doi | 10.1016/j.clineuro.2016.12.006 | - |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.pmid | 28013184 | en_US |
dc.identifier.scopus | 2-s2.0-85007240653 | en_US |
dc.identifier.wos | WOS:000394632300009 | en_US |
dc.identifier.scopusquality | Q2 | - |
dc.owner | Pamukkale University | - |
item.openairetype | Article | - |
item.languageiso639-1 | en | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
item.fulltext | No Fulltext | - |
item.grantfulltext | none | - |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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