Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/9130
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dc.contributor.authorCeylan, B.-
dc.contributor.authorArslan, F.-
dc.contributor.authorSipahi, O.R.-
dc.contributor.authorSunbul, M.-
dc.contributor.authorOrmen, B.-
dc.contributor.authorHakyemez, İ.N.-
dc.contributor.authorTurunc, T.-
dc.date.accessioned2019-08-16T12:58:29Z
dc.date.available2019-08-16T12:58:29Z
dc.date.issued2017-
dc.identifier.issn0303-8467-
dc.identifier.urihttps://hdl.handle.net/11499/9130-
dc.identifier.urihttps://doi.org/10.1016/j.clineuro.2016.12.006-
dc.description.abstractAim To examine the variables associated with mortality in patients with Acinetobacter baumannii-related central nervous system infections treated with intrathecal colistin. Materials and methods This multi-centre retrospective case control study included patients from 11 centres in Turkey, as well as cases found during a literature review. Only patients with CNS infections caused by multidrug-resistant or extensively drug-resistant Acinetobacter baumannii treated with intrathecal colistin were included in this study. The variables associated with mortality were determined by dividing the patients into groups who died or survived during hospitalisation, and who died or survived from Acinetobacter meningitis. Results Among the 77 cases enrolled in the study, 35 were found through a literature review and 42 were cases from our centres. Forty-four cases (57.1%) were male and the median age was 48 years (range: 20–78 years). Thirty-seven patients (48%) died during hospitalisation. The variables associated with increased all-cause mortality during hospitalisation included old age (odds ratio, 1.035; 95% confidence interval (CI), 1.004–1.067; p = 0.026) and failure to provide cerebrospinal fluid sterilisation (odds ratio, 0.264; 95% confidence interval, 0.097–0.724; p = 0.01). There is a trend (P = 0.062) towards higher mortality with using of meropenem during meningitis treatment. Fifteen cases (19%) died from meningitis. There were no significant predictors of meningitis-related mortality. Conclusions The mortality rate for central nervous system infections caused by multidrug-resistant or extensively drug-resistant Acinetobacter baumannii is high. Old age and failure to provide CSF sterilisation are associated with increased mortality during hospitalisation. © 2016en_US
dc.language.isoenen_US
dc.publisherElsevier B.V.en_US
dc.relation.ispartofClinical Neurology and Neurosurgeryen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcinetobacter baumanniien_US
dc.subjectColistinen_US
dc.subjectIntratechalen_US
dc.subjectMeningitisen_US
dc.subjectamikacinen_US
dc.subjectcefazolinen_US
dc.subjectcefepimeen_US
dc.subjectceftazidimeen_US
dc.subjectceftriaxoneen_US
dc.subjectcefuroximeen_US
dc.subjectciprofloxacinen_US
dc.subjectcolistinen_US
dc.subjectgentamicinen_US
dc.subjectimipenemen_US
dc.subjectlevofloxacinen_US
dc.subjectlinezoliden_US
dc.subjectmeropenemen_US
dc.subjectpiperacillin plus tazobactamen_US
dc.subjectrifampicinen_US
dc.subjectsulbactamen_US
dc.subjectteicoplaninen_US
dc.subjecttigecyclineen_US
dc.subjectvancomycinen_US
dc.subjectantiinfective agenten_US
dc.subjectthienamycin derivativeen_US
dc.subjectAcinetobacter infectionen_US
dc.subjectadulten_US
dc.subjectageden_US
dc.subjectantibiotic therapyen_US
dc.subjectArticleen_US
dc.subjectbacterial meningitisen_US
dc.subjectbrain ventriculitisen_US
dc.subjectcase control studyen_US
dc.subjectcentral nervous system infectionen_US
dc.subjectcerebrospinal fluiden_US
dc.subjectdisease associationen_US
dc.subjectfemaleen_US
dc.subjecthumanen_US
dc.subjectmajor clinical studyen_US
dc.subjectmaleen_US
dc.subjectmiddle ageden_US
dc.subjectmortalityen_US
dc.subjectmulticenter studyen_US
dc.subjectnonhumanen_US
dc.subjectretrospective studyen_US
dc.subjectyoung adulten_US
dc.subjectAcinetobacter Infectionsen_US
dc.subjectCerebral Ventriculitisen_US
dc.subjectclinical trialen_US
dc.subjectintraspinal drug administrationen_US
dc.subjectMeningitis, Bacterialen_US
dc.subjectoutcome assessmenten_US
dc.subjectpathogenicityen_US
dc.subjectAdulten_US
dc.subjectAgeden_US
dc.subjectAnti-Bacterial Agentsen_US
dc.subjectCase-Control Studiesen_US
dc.subjectFemaleen_US
dc.subjectHumansen_US
dc.subjectInjections, Spinalen_US
dc.subjectMaleen_US
dc.subjectMiddle Ageden_US
dc.subjectOutcome Assessment (Health Care)en_US
dc.subjectRetrospective Studiesen_US
dc.subjectThienamycinsen_US
dc.subjectYoung Adulten_US
dc.titleVariables determining mortality in patients with Acinetobacter baumannii meningitis/ventriculitis treated with intrathecal colistinen_US
dc.typeArticleen_US
dc.identifier.volume153en_US
dc.identifier.startpage43
dc.identifier.startpage43en_US
dc.identifier.endpage49en_US
dc.identifier.doi10.1016/j.clineuro.2016.12.006-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.pmid28013184en_US
dc.identifier.scopus2-s2.0-85007240653en_US
dc.identifier.wosWOS:000394632300009en_US
dc.identifier.scopusqualityQ2-
dc.ownerPamukkale University-
item.openairetypeArticle-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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