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https://hdl.handle.net/11499/9130
Title: | Variables determining mortality in patients with Acinetobacter baumannii meningitis/ventriculitis treated with intrathecal colistin | Authors: | Ceylan, B. Arslan, F. Sipahi, O.R. Sunbul, M. Ormen, B. Hakyemez, İ.N. Turunc, T. |
Keywords: | Acinetobacter baumannii Colistin Intratechal Meningitis amikacin cefazolin cefepime ceftazidime ceftriaxone cefuroxime ciprofloxacin colistin gentamicin imipenem levofloxacin linezolid meropenem piperacillin plus tazobactam rifampicin sulbactam teicoplanin tigecycline vancomycin antiinfective agent thienamycin derivative Acinetobacter infection adult aged antibiotic therapy Article bacterial meningitis brain ventriculitis case control study central nervous system infection cerebrospinal fluid disease association female human major clinical study male middle aged mortality multicenter study nonhuman retrospective study young adult Acinetobacter Infections Cerebral Ventriculitis clinical trial intraspinal drug administration Meningitis, Bacterial outcome assessment pathogenicity Adult Aged Anti-Bacterial Agents Case-Control Studies Female Humans Injections, Spinal Male Middle Aged Outcome Assessment (Health Care) Retrospective Studies Thienamycins Young Adult |
Publisher: | Elsevier B.V. | Abstract: | Aim To examine the variables associated with mortality in patients with Acinetobacter baumannii-related central nervous system infections treated with intrathecal colistin. Materials and methods This multi-centre retrospective case control study included patients from 11 centres in Turkey, as well as cases found during a literature review. Only patients with CNS infections caused by multidrug-resistant or extensively drug-resistant Acinetobacter baumannii treated with intrathecal colistin were included in this study. The variables associated with mortality were determined by dividing the patients into groups who died or survived during hospitalisation, and who died or survived from Acinetobacter meningitis. Results Among the 77 cases enrolled in the study, 35 were found through a literature review and 42 were cases from our centres. Forty-four cases (57.1%) were male and the median age was 48 years (range: 20–78 years). Thirty-seven patients (48%) died during hospitalisation. The variables associated with increased all-cause mortality during hospitalisation included old age (odds ratio, 1.035; 95% confidence interval (CI), 1.004–1.067; p = 0.026) and failure to provide cerebrospinal fluid sterilisation (odds ratio, 0.264; 95% confidence interval, 0.097–0.724; p = 0.01). There is a trend (P = 0.062) towards higher mortality with using of meropenem during meningitis treatment. Fifteen cases (19%) died from meningitis. There were no significant predictors of meningitis-related mortality. Conclusions The mortality rate for central nervous system infections caused by multidrug-resistant or extensively drug-resistant Acinetobacter baumannii is high. Old age and failure to provide CSF sterilisation are associated with increased mortality during hospitalisation. © 2016 | URI: | https://hdl.handle.net/11499/9130 https://doi.org/10.1016/j.clineuro.2016.12.006 |
ISSN: | 0303-8467 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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