Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/9130
Title: Variables determining mortality in patients with Acinetobacter baumannii meningitis/ventriculitis treated with intrathecal colistin
Authors: Ceylan, B.
Arslan, F.
Sipahi, O.R.
Sunbul, M.
Ormen, B.
Hakyemez, İ.N.
Turunc, T.
Keywords: Acinetobacter baumannii
Colistin
Intratechal
Meningitis
amikacin
cefazolin
cefepime
ceftazidime
ceftriaxone
cefuroxime
ciprofloxacin
colistin
gentamicin
imipenem
levofloxacin
linezolid
meropenem
piperacillin plus tazobactam
rifampicin
sulbactam
teicoplanin
tigecycline
vancomycin
antiinfective agent
thienamycin derivative
Acinetobacter infection
adult
aged
antibiotic therapy
Article
bacterial meningitis
brain ventriculitis
case control study
central nervous system infection
cerebrospinal fluid
disease association
female
human
major clinical study
male
middle aged
mortality
multicenter study
nonhuman
retrospective study
young adult
Acinetobacter Infections
Cerebral Ventriculitis
clinical trial
intraspinal drug administration
Meningitis, Bacterial
outcome assessment
pathogenicity
Adult
Aged
Anti-Bacterial Agents
Case-Control Studies
Female
Humans
Injections, Spinal
Male
Middle Aged
Outcome Assessment (Health Care)
Retrospective Studies
Thienamycins
Young Adult
Publisher: Elsevier B.V.
Abstract: Aim To examine the variables associated with mortality in patients with Acinetobacter baumannii-related central nervous system infections treated with intrathecal colistin. Materials and methods This multi-centre retrospective case control study included patients from 11 centres in Turkey, as well as cases found during a literature review. Only patients with CNS infections caused by multidrug-resistant or extensively drug-resistant Acinetobacter baumannii treated with intrathecal colistin were included in this study. The variables associated with mortality were determined by dividing the patients into groups who died or survived during hospitalisation, and who died or survived from Acinetobacter meningitis. Results Among the 77 cases enrolled in the study, 35 were found through a literature review and 42 were cases from our centres. Forty-four cases (57.1%) were male and the median age was 48 years (range: 20–78 years). Thirty-seven patients (48%) died during hospitalisation. The variables associated with increased all-cause mortality during hospitalisation included old age (odds ratio, 1.035; 95% confidence interval (CI), 1.004–1.067; p = 0.026) and failure to provide cerebrospinal fluid sterilisation (odds ratio, 0.264; 95% confidence interval, 0.097–0.724; p = 0.01). There is a trend (P = 0.062) towards higher mortality with using of meropenem during meningitis treatment. Fifteen cases (19%) died from meningitis. There were no significant predictors of meningitis-related mortality. Conclusions The mortality rate for central nervous system infections caused by multidrug-resistant or extensively drug-resistant Acinetobacter baumannii is high. Old age and failure to provide CSF sterilisation are associated with increased mortality during hospitalisation. © 2016
URI: https://hdl.handle.net/11499/9130
https://doi.org/10.1016/j.clineuro.2016.12.006
ISSN: 0303-8467
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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