Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/9380
Title: Increased erythrocyte aggregation in patients with primary open angle glaucoma
Authors: Kılıç-Toprak, Emine
Toprak, I.
Kılıç-Erkek, Özgen
Küçükatay, Vural
Bor-Küçükatay, Melek
Keywords: erythrocyte aggregation
optic nerve head
optical coherence tomography
primary open angle glaucoma
red blood cell deformability
adult
aged
blood
erythrocyte deformability
female
Glaucoma, Open-Angle
human
male
middle aged
nerve fiber
pathology
prospective study
retina ganglion cell
Adult
Aged
Erythrocyte Aggregation
Erythrocyte Deformability
Female
Humans
Male
Middle Aged
Nerve Fibers
Prospective Studies
Retinal Ganglion Cells
Tomography, Optical Coherence
Publisher: Blackwell Publishing Ltd
Abstract: Background: The rationale of this study is to determine alterations in blood rheology (erythrocyte aggregation and deformability) and relationship between structural measurements obtained from optical coherence tomography (OCT) in different stages of primary open angle glaucoma (POAG). Methods: This prospective controlled study comprised 23 POAG patients (glaucoma group) and 23 age- and sex-matched healthy subjects (control group). Elongation index (EI), which is the indicator of erythrocyte deformability and erythrocyte aggregation was measured using an ektacytometer. Optic nerve head (ONH) morphology and peripapillary retinal nerve fibre layer (RNFL) thickness were evaluated using a spectral domain (SD) OCT. Results: There were no significant differences between the groups regarding the elongation index values (p > 0.05). On the other hand, erythrocyte aggregation amplitude (AMP) and mean corpuscular haemoglobin concentration (MCHC) were significantly higher in the glaucoma group than in the control group (p = 0.015, p = 0.003 respectively). A significant correlation was also found between the elongation index and retinal nerve fibre layer (average and superior) thickness (p < 0.05) in patients with late glaucoma. Conclusions: In patients with POAG, erythrocyte aggregation appears to be higher. It can be speculated that higher erythrocyte aggregation and deformability may be involved in the pathogenesis of glaucoma by affecting microperfusion of the optic nerve head and retina. Modification of rheological parameters in patients with glaucoma may be considered as an adjuvant future therapy in glaucoma management, whereas further studies in larger groups are needed. © 2016 Optometry Australia
URI: https://hdl.handle.net/11499/9380
https://doi.org/10.1111/cxo.12388
ISSN: 0816-4622
Appears in Collections:Denizli Sağlık Hizmetleri Meslek Yüksekokulu Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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