Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/9440
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dc.contributor.authorDoğanlı, Gülümser Acar-
dc.date.accessioned2019-08-16T13:01:30Z
dc.date.available2019-08-16T13:01:30Z
dc.date.issued2016-
dc.identifier.issn1307-6167-
dc.identifier.urihttps://hdl.handle.net/11499/9440-
dc.description.abstractAntibiofilm properties and the phenolic composition of propolis, collected from Bartın province of Turkey in the years of 2013 and 2012, were determined. Hexane, ethyl acetate and ethanol extracts of propolis were prepared and assessed for their antibiofilm activity (inhibition of biofilm formation and reduction of established biofilm) against the clinical methicillin sensitive Staphylococcus aureus (MSSA) strains and Staphylococcus aureus ATCC 33862. Ethyl acetate and ethanol extracts of propolis presented a greater effectiveness on biofilm inhibition of the tested bacteria compared to hexane extracts. The activity patterns showed slight variations in the two years. While 0.5 mg/mL ethyl acetate, ethanol and hexane extract solutions of the product in 2013 inhibited 92.89, 82.98 and 47.42% of biofilm formation of MSSA M20 strain, the inhibition percentage of the products of 2012 were determined to be 87.14%, 75.94% and 44.89% against the same bacterium (MSSA M20), respectively. The results of the validated liquid chromatography-electrospray tandem mass spectrometry (UPLC-ESI-MS/MS) analyses showed a strong relation between the activity and the phenolic composition of the extracts. Phenolic contents of the ethyl acetate and ethanol extracts were relatively higher than hexane extracts. Caffeic acid composition of ethyl acetate, ethanol and hexane extracts of the product in 2013 was detected as 23521.0, 16881.0 and 3522.8 µg/g, respectively. On the other hand, the caffeic acid contents of the product of 2012 was found to be lower than those of 2013 (19100.0, 10416.0 and 2322.5 µg/g for ethyl acetate, ethanol and hexane extracts, respectively). Consequently, the findings have shown that propolis extracts possessed good antibiofilm activity against clinical staphylococci, and its phenolic composition has been affected by the year of collection. © 2016 ACG Publications. All rights reserved.en_US
dc.language.isoenen_US
dc.publisherACG Publicationsen_US
dc.relation.ispartofRecords of Natural Productsen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAntibiofilmen_US
dc.subjectMSSAen_US
dc.subjectPhenolic compoundsen_US
dc.subjectPrincipal component analysisen_US
dc.subjectPropolisen_US
dc.subjectUPLC-ESIMS/ MSen_US
dc.subjectacetic acid ethyl esteren_US
dc.subjectalcoholen_US
dc.subjectcaffeic aciden_US
dc.subjecthexaneen_US
dc.subjectphenol derivativeen_US
dc.subjectpropolisen_US
dc.subjectApis melliferaen_US
dc.subjectArticleen_US
dc.subjectbiofilmen_US
dc.subjectchemical compositionen_US
dc.subjectliquid chromatographyen_US
dc.subjectmethicillin susceptible Staphylococcus aureusen_US
dc.subjectnonhumanen_US
dc.subjectprincipal component analysisen_US
dc.subjectStaphylococcus aureusen_US
dc.subjecttandem mass spectrometryen_US
dc.subjectTurkey (republic)en_US
dc.titlePhenolic content and antibiofilm activity of propolis against clinical MSSA strainsen_US
dc.typeArticleen_US
dc.identifier.volume10en_US
dc.identifier.issue5en_US
dc.identifier.startpage617
dc.identifier.startpage617en_US
dc.identifier.endpage627en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.scopus2-s2.0-84959475679en_US
dc.identifier.wosWOS:000372804700010en_US
dc.identifier.scopusqualityQ3-
dc.ownerPamukkale University-
item.openairetypeArticle-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextWith Fulltext-
item.languageiso639-1en-
item.grantfulltextopen-
Appears in Collections:Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Teknoloji Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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