Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/9442
Title: Topical ketoprofen versus placebo in treatment of acute ankle sprain in the emergency department
Authors: Serinken, Mustafa
Eken, C.
Elicabuk, H.
Keywords: ankle sprain
emergency department
ketoprofen
topical
placebo
ketoprofen topical gel
nonsteroid antiinflammatory agent
absence of side effects
adult
Article
comparative effectiveness
controlled clinical trial
controlled study
double blind procedure
emergency ward
female
gel
human
intention to treat analysis
major clinical study
male
pain intensity
pain measurement
priority journal
prospective study
topical treatment
visual analog scale
analogs and derivatives
Ankle Injuries
hospital emergency service
pain
Sprains and Strains
treatment outcome
Anti-Inflammatory Agents, Non-Steroidal
Double-Blind Method
Emergency Service, Hospital
Humans
Ketoprofen
Pain
Pain Measurement
Prospective Studies
Treatment Outcome
Publisher: SAGE Publications Inc.
Abstract: Background: Topical agents have been shown to be effective in soft tissue injuries and commonly used in outpatient clinics. However, the data regarding topical agents in the emergency department is insufficient, and they are not used often in the emergency department setting. The present study aimed to compare the effect of 2.5% topical ketoprofen (gel form) to placebo in patients presenting with ankle sprain to the emergency department. Methods: Patients presenting with ankle sprain composed the study population. Study patients were randomized into 2 study arms: 2.5% ketoprofen gel and placebo administered over a 5-cm area locally. Pain alleviation was measured by visual analog scale at 15 and 30 minutes. A total of 100 patients were included in the final analysis. Results: The median pain reduction in ketoprofen and placebo groups at 15 minutes was 27 (19.8-33.4) and 9 (7.6-17), respectively. The median pain reduction at 30 minutes for both groups was 42 (36-50.8) and 20 (17.6-24.4), respectively. Pain improvement either at 15 minutes (median difference: 16 [9-22]) or 30 minutes (median difference: 21 [15-27]) was better in the ketoprofen group than placebo. There were no adverse effects in either group. Conclusion: Ketoprofen gel was superior to placebo at 30 minutes in alleviating pain secondary to ankle sprain in the ED with a high safety profile. Further studies are needed concerning the effect of ketoprofen gel for long-term effects. Level of Evidence: Level I, high quality prospective randomized study. © The Author(s) 2016.
URI: https://hdl.handle.net/11499/9442
https://doi.org/10.1177/1071100716650530
ISSN: 1071-1007
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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