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  • Article
    Aesthetic Interventions in Patients with Allergic Skin Diseases: Risk Assessment and Evidence-Based Preventive Risk Management
    (Elsevier Inc., 2026-03) Yiğit, İçim Kömürcügil; Türsen, Ümit; Türsen, Belma; Solak, Berna; Bakay, Özge Sevil Karstarlı; Kroumpouzos, George
  • Article
    Probiotics for Skin Aging and Skin Conditions in the Elderly
    (Elsevier Inc., 2026-02) Yiğit, İçim Kömürcügil; Türsen, Ümit; Türsen, Belma; Solak, Berna; Bakay, Özge Sevil Karstarlı; Kroumpouzos, George
  • Article
    Tideglusib Accelerates Bone-Tendon Interface Healing and Improves Mechanical Strength in a Rabbit Rotator Cuff Tear Model: An Experimental Study
    (BMC, 2026-02-14) Ocaklar, Zeynel Can; Unal, Murat Serkant; Yorukoglu, A. Cagdas
    Background The present study aimed to investigate the effects of the glycogen synthase kinase-3 (GSK-3) inhibitor tideglusib on bone-tendon interface healing in a rabbit model of rotator cuff injury, based on biomechanical and histological assessments. Methods Fourteen New Zealand rabbits underwent supraspinatus tendon detachment to establish a chronic rotator cuff tear model. After six weeks, surgical repair was performed. In the right shoulders, tideglusib was administered at the bone-tendon junction prior to performing the primary repair (drug group), whereas the left shoulders underwent primary repair without biological augmentation (control group). Seven animals were included in the group subjected to biomechanical tension testing, and six for histological evaluation. Results Biomechanical evaluation demonstrated that the tideglusib group showed significantly higher load-to-failure values compared with the control group the control group (p < 0.05), whereas elongation at failure showed no statistically significant difference. Histological scoring demonstrated significantly improved cellular organization and tissue healing in the tideglusib group (p < 0.05). Conclusion Local application of tideglusib positively enhances tendon-bone healing both biomechanically and histologically. Further studies are warranted to explore its potential clinical applications.
  • Article
    The Time-Dependent Effects of Temozolomide on Autophagy Gene Expression in Glioblastoma Cells
    (MDPI, 2026-03-13) Kiraz, Ilker; Aydin, Veli Kaan; Kurt, Ozgur; Coskun, Mehmet Erdal; Lengerova, Gergana; Bozhkova, Martina; Petrov, Steliyan; Koseler, Aylin
    Background: Temozolomide (TMZ) resistance represents a major therapeutic challenge in glioblastoma treatment, where autophagy has emerged as a key adaptive survival mechanism. Although numerous studies have implicated autophagy in TMZ resistance, most have assessed this process at a single point, thereby overlooking its dynamic and time-dependent nature. Methods: In this study, we systematically investigated the temporal regulation of autophagy-related gene expression in two human glioblastoma cell lines with distinct MGMT methylation status and TMZ sensitivities (T98G and U87) following TMZ treatment. Cells were exposed to TMZ and harvested at defined time points (0 h, 6 h, 24 h, and 48 h). The expression levels of genes representing distinct stages of the autophagy pathway, including initiation, nucleation, elongation, selective autophagy, lysosomal function, and transcriptional regulation, were analyzed using RT-qPCR. Relative gene expression was calculated using the 2-Delta Delta CT method with GAPDH as the reference gene. Results: Our results reveal a time-dependent and phase-specific transcriptional reprogramming of the autophagy machinery in response to TMZ-induced stress. Early time points were characterized by modulation of autophagy initiation and nucleation genes, whereas intermediate and late phases showed prominent regulation of genes associated with autophagosome elongation, selective autophagy, autophagic flux, and transcriptional control. Conclusions: Collectively, these findings demonstrate that autophagy in TMZ-treated glioblastoma cells is not a static response but a dynamically regulated, multi-phase program. Specifically, in TMZ-resistant T98G cells, this process matures into a sustained adaptive program with robust late-phase lysosomal integration, while in TMZ-sensitive U87 cells, the early autophagic response is transient and fails to support long-term lysosomal coordination. This temporal perspective provides new insights into the role of autophagy in TMZ tolerance and underscores the importance of time-resolved analyses when targeting autophagy to overcome chemoresistance in glioblastoma.
  • Article
    The Academic Hunger Gap: From Plates to Well-Being-How Food Insecurity Undermines Quality of Life in University Students
    (Wiley, 2026-03) Kandemir, Ummuhan Inci; Uzun, Suleyman Utku
    Food insecurity, a significant global challenge, is increasingly recognized among university students, potentially impacting their quality of life (QoL). This study aimed to assess the prevalence of food insecurity and its association with QoL among university students in Denizli, Türkiye. A cross-sectional study was conducted among 1495 university students. Food insecurity was assessed using the Household Food Insecurity Access Scale (HFIAS), categorized as food secure, mild, moderate, or severe insecurity. Quality of life was measured with the SF-12, yielding Physical Component Summary (PCS) and Mental Component Summary (MCS) scores. Multiple linear regression analyses were performed to identify predictors of physical (PCS) and mental (MCS) components of quality of life. The prevalence of food insecurity was 44.9%, with 20.9% experiencing mild, 16.0% moderate, and 8.0% severe food insecurity. Food-insecure students had significantly lower PCS (50.16 +/- 8.05 vs. 52.50 +/- 6.89, p < 0.001) and MCS scores (38.24 +/- 10.30 vs. 41.58 +/- 10.28, p < 0.001) compared to food-secure students. A dose-response was observed; increasing food insecurity severity correlated with decreasing PCS and MCS scores (p < 0.001 for both). In multivariable models, food insecurity remained an independent negative predictor of PCS and MCS, alongside other factors such as income, chronic disease, smoking, and gender. Food insecurity affects nearly half of university students and is significantly associated with poorer physical and mental quality of life, even after controlling for various confounding factors. These findings highlight the urgent need for targeted university interventions including campus food assistance programs, enhanced financial aid policies to address food insecurity and improve student well-being.
  • Article
    Slow-Releasing CO Donor CORM-A1 Modulates Depression-like Behavior in Experimental Model of Chronic Prostatitis/Chronic Pelvic Pain Syndrome
    (Nencki Institute of Experimental Biology, 2026-02-20) Šutulović, Nikola; Ezgin, Neriman; Djurić, Emilija; Grubač, Željko; Vesković, Milena; Mladenović, Dušan; Dodurga, Yavuz; Marković, Aleksandra Rašić; Stanojlović, Olivera; Hrnčić, Dragan
  • Article
    Resectable Stage Early-Onset Biliary Tract Cancer: Survival and Prognostic Scoring (EOB-RS and EOB-OS) in Turkish Patients (TOG/GI-SAFRADJU-2502-EO)
    (Lippincott Williams & Wilkins, 2026-03) Akkus, Erman; Kayaalp, Mehmet; Ergözoğlu, Müzeyyen Aslı; Koç Kuş, Ilgın; Bayram, Doğan; Kılıçtaş, Bilgeşah; Ayvaz Güneyin, Emel ; Kalem, Ali; Temizyürek, Haydar; Çatlı, Mehmet Mutlu; Akarca, Mehmet Sinan; Mıldanoğlu, Maral Martin; Turhan, Görkem; Kara, Mahmut; Arak, Hacı; Arslan Tan, Feyza; Paçacı, Burak; Yeşilyurt, Berkay; Akdoğan, Orhun; Ala Enli, Şeymanur; Yasar, Hatime Arzu
    PURPOSE Early-onset gastrointestinal cancers are concerning entities globally, yet early-onset biliary tract cancers (EOBTCs) are understudied. Early-stage disease is crucial for young patients' survival. METHODS TOG/GI-SAFRADJU (ClinicalTrials.gov identifier: NCT06975917) is a multicenter, hospital-based, registry initiative of the Turkish Oncology Group, including patients with resected BTCs. Early-onset was defined as a diagnosis at age <50 years. Characteristics and survival of EOBTC and non-EOBTC were compared. Among patients with EOBTC, prognostic factors for recurrence-free survival (RFS) and overall survival (OS) were analyzed. Risk scores were assigned on the basis of hazard ratios. RESULTS Six hundred seventeen patients from 44 centers were included. 12.6% (n = 78) were EOBTC. R1 resection rate was significantly higher among EOBTC (37.1% v 25.7%, P = .038). Adjuvant treatments did not differ between EOBTC and non-EOBTC. Among patients who received adjuvant chemotherapy, RFS (13.9 months [95% CI, 11.4 to 22.1] v 15.9 months [95% CI, 13.6 to 18.9], P = .947) and OS (35.6 months [95% CI, 28.0 to 81.4] v 31.3 months [95% CI, 27.8 to 44.3], P = .670) were similar between EOBTC and non-EOBTC groups. Among patients with EOBTC, R1-resection and high CA19-9 levels were associated with shorter RFS, and gallbladder localization and high CA19-9 were associated with shorter OS in adjusted analyses. Using these factors, risk scores early-stage EOBTC RFS score (EOB-RS) for RFS and early-stage EOBTC OS score (EOB-OS) for OS were formed, each including three ranks. Both scores significantly ordered the prognosis of patients with EOBTC (EOB-RS, [0 points]: 22.7 months, [1 or 2]: 10.3 months, [3]: 5.7 months, P < .001, EOB-OS: [0]: 110.9 months, [1 or 2]: 29.6 months, [3]: 10.1 months, P < .001). CONCLUSION Resected EOBTC patients showed survival comparable to older counterparts receiving surgery/adjuvant therapy. This study suggests a potential risk scoring system for early-stage EOBTC, pending validation.
  • Article
    Real-World Outcomes of Trastuzumab Deruxtecan in Patients with HER2+ Metastatic Breast Cancer: Turkish Oncology Group Multicenter Study
    (SAGE Publications Ltd, 2026-03) Sahin, Taha Koray; Kemik, Fatih; Muglu, Harun; Acikgöz Yildiz, Bedriye; Biter, Sedat; Tunbekici, Salih; Oruc, Ahmet; Guren, Ali Kaan; Kaban, Kerim; Guzel, Halil Goksel; Erol, Cihan; Aykan, Musa Baris; Koylu, Bahadir; Ekinci, Omer Burak; Deliktas Onur, Ilknur; Aksoy, Sercan
    Background: Trastuzumab deruxtecan (T-DXd) has transformed the treatment landscape of human epidermal growth factor receptor 2-positive (HER2+) metastatic breast cancer (mBC), with significant improvements in survival reported in clinical trials. However, limited data exist regarding its performance in real-world settings, particularly in lower-middle-income countries (LMICs).Objectives: To evaluate the real-world effectiveness and safety of T-DXd in patients with HER2+ mBC in Turkiye. Design: A multicenter retrospective cohort study. Methods: This multicenter, retrospective cohort study, conducted by the Turkish Oncology Group, evaluated the real-world outcomes and tolerability of T-DXd in patients with HER2+ mBC across 27 oncology centers in Türkiye. The primary endpoints were real-world progression-free survival (rwPFS) and overall survival (rwOS). Secondary endpoints included response rate, safety (with adverse events (AEs) graded according to CTCAE v5.0), and evaluation of the first post-T-DXd treatments. Results: A total of 269 patients were included. The median age was 49 years (interquartile range: 42-59), and the median follow-up was 12.9 months. The median rwPFS was 17.9 months (95% confidence interval: 13.3-22.5), and the median rwOS was 35.7 months (95% confidence interval: 27.8-43.6). The objective response rate was 71.4%, and the disease control rate was 95.2%. Patients receiving T-DXd in the second line experienced significantly longer rwPFS compared with those treated in later lines (p < 0.001). Treatment-related AEs of any grade occurred in 68.4% of patients. Interstitial lung disease was reported in 21 patients (7.8%), with 4 cases being grade >= 3. Conclusion: In this large national real-world cohort from an LMIC, T-DXd demonstrated robust antitumor activity and a manageable safety profile in patients with HER2+ mBC. These findings are consistent with prior clinical trial data and support the applicability of T-DXd in broader clinical settings.
  • Correction
    Manyetik Rezonans Görüntüleme ile Yaşa ve Cinsiyete Göre İnterpedünküler Açı Değerlerinin Değerlendirilmesi
    (2025) Arslan, Yusuf Kemal; Oğuz, Özkan; Şafak, Nazire Kılıç; Bozdağ, Zekiye Karaca; Erdem, Huseyin; Boyan, Neslihan; Aygün, Danıs
    Bu çalışma, sağlıklı yetişkin bir popülasyonda manyetik rezonans görüntüleme (MRI) kullanarak interpedünküler açı (IPA), pontomesensefalik açı (PMA) ve pontomedüller açı için normatif, yaşa ve cinsiyete göre tabakalandırılmış referans değerleri belirlemeyi amaçlamaktadır. Gereç ve Yöntemler: Bu retrospektif çalışmaya Ocak 2018 ile Aralık 2020 arasında beyin MRI'ı çekilen 290 sağlıklı yetişkin hasta (124 erkek, 166 kadın; ortalama yaş: 43,1 ± 16,7 yıl) dahil edildi. IPA, PMA ve pontomedüller açılar, standartlaştırılmış aksiyel ve orta sagital T1 ağırlıklı spin-eko MRI dizilerinde ölçüldü. Sınıflandırma şu şekildeydi: 18-24 yaş (genç yetişkinler), 25-33 yaş (yetişkinler), 34-48 yaş (erken orta yaşlı), 49-64 yaş (orta yaşlı), ≥65 yaş (yaşlı). Sonuçlar: Ortalama IPA 75,5° ± 10,2, PMA 57,0° ± 10,2 ve pontomedüller açı 133,8° ± 10,6 idi. Erkek ve kadınlar arasında herhangi bir açısal ölçümde anlamlı bir fark gözlenmedi (p &gt; 0,05). Ancak, özellikle orta yaşlı ve yaşlı gruplarında, ilerleyen yaşla birlikte IPA değerlerinde anlamlı bir artış gözlendi (p &lt; 0,001). IPA yaşla orta düzeyde pozitif bir korelasyon gösterdi (r = 0,372; p &lt; 0,001), PMA ve pontomedüller açı ise yaşla anlamlı bir korelasyon göstermedi. Üç açısal parametre arasında anlamlı bir korelasyon bulunamadı. Sonuç: IPA değerleri yaşla birlikte önemli ölçüde artarken, PMA ve pontomedüller açılar yetişkinlik boyunca nispeten sabit kaldı. Bu bulgular, beyin sapı açısal ölçümleri için normatif, yaşa ve cinsiyete göre sınıflandırılmış referans verileri sağlar ve bu da klinik tanılamada, özellikle spontan intrakraniyal hipotansiyon ve nörodejeneratif sendromlar gibi durumlarda, bunların kullanımını artırabilir.
  • Article
    Late Diagnosis of Jervell and Lange-Nielsen Syndrome in Two Sisters with Homozygous KCNQ1 Mutation
    (Cambridge Univ Press, 2026-04-06) Kocaekiz, Peruze; Tokgun, Onur; Yilmaz, Samet
    Jervell and Lange-Nielsen syndrome is a rare inherited disorder characterised by sensorineural hearing loss and a prolonged corrected QT interval, predisposing to malignant arrhythmias. We describe two adult sisters diagnosed after recurrent syncope. Genetic testing confirmed a homozygous KCNQ1 mutation. Awareness of this condition, even in adulthood, is essential to ensure diagnosis, appropriate treatment, and prevention of sudden cardiac death.