Denizli Sağlık Hizmetleri Meslek Yüksekokulu Koleksiyonu
Permanent URI for this collectionhttps://hdl.handle.net/11499/46014
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Article Exploring the Influence of Alkaline Earth Fluorides on the Structural and Spectroscopic Properties of Dy3+ Doped Oxyfluoride Borogermanate Glasses for Photonic Applications(Elsevier Ltd, 2026-04) Kocyigit-Kaplan, Deniz; Gokce, Melis; Gokce, Aytac GurhanRecent advances in photonic technologies have become integral to modern life, with applications in light emitting diodes, lasers and displays, all requiring highly efficient luminescent materials. To meet this requirement DyF<inf>3</inf> doped oxyfluoride borogermanate glasses were fabricated by the melt-quenching technique to investigate the effect of alkaline earth fluorides such as BaF<inf>2</inf>, SrF<inf>2</inf> and CaF<inf>2</inf>. The density, molar volume, refractive index, critical distance and polaron radius all follow the same increasing trend in CaF<inf>2</inf><SrF<inf>2</inf><BaF<inf>2</inf>. FT-IR analysis revealed that the CaF<inf>2</inf> doped glass network exhibits a more compact structure due to the higher concentration of [BO<inf>4</inf>] units. The ligand field around the Dy3+ ions and the ionic nature of the glass network were verified by estimating bonding parameters. The Judd-Ofelt intensity parameters indicate a stronger Dy-O covalency and lower asymmetry in the CaF<inf>2</inf> doped (BGA-Ca) sample than in the other samples. For the 4F<inf>9/2</inf>→6H<inf>13/2</inf> transition, the BGA-Ca glass exhibits the highest values of branching ratio, stimulated emission cross-section and optical gain bandwidth among all the glasses investigated. The decay time values of the 4F<inf>9/2</inf> level were found by fitting a single exponential curve. The chromaticity coordinates of oxyfluoride borogermanate glasses are centered near the white light region and the color correlated temperature and color purity values are in the neutral white light region. Among all glasses, BGA-Ca glass has the highest color purity value (42%). The results demonstrate the usability of all studied glasses in photonic applications such as laser action and white light generation. © 2025 Elsevier LtdArticle Citation - WoS: 1High-Performance Multiparametric Luminescent Thermometer: Dy3+-Doped Sodium Alumino-Borate Glass(Elsevier, 2025-12) Ciric, Aleksandar; Gokce, Aytac Gurhan; Gokce, Melis; Kuzman, Sanja; Ristic, Zoran; Milicevic, Bojana; Kocyigit, Deniz; Dramićanin, Miroslav D.This work presents a comprehensive study of high-performance multiparametric luminescent thermometry using Dy3+-doped sodium alumino-borate glass. The glass was synthesized via the melt-quenching method and characterized structurally and optically. Temperature-dependent luminescence properties were investigated, focusing on the luminescence intensity ratio (LIR) of thermally coupled Dy3+ transitions, as well as emission bandwidth and line shift. The Judd-Ofelt model was applied to interpret the thermometric behaviour, showing excellent agreement with experimental results. While the luminescence lifetime remained temperature-invariant, making the material unsuitable for lifetime-based thermometry, steady-state spectral features provided high sensitivity and precision. Multiparametric approaches, including multiple linear regression (MLR) and sensor fusion (SF), were employed to combine different readouts, resulting in enhanced temperature resolution and robustness. The sensor fusion method, in particular, outperformed individual and MLR-based approaches, achieving sub-kelvin temperature resolution at all temperatures. These findings demonstrate that Dy3+-doped sodium aluminoborate glass is a promising candidate for reliable, high-precision luminescent thermometry in demanding environments and the power of multiparametric methods MLR and SF over the individual parameters.Article The Role of Micro-RNA200 in Implantation of Embryo to Endometrium(Springernature, 2025-08-21) Akgun, Ayse; Mete, Gulcin Abban; Cil, Nazli; Unal, M. SerkantThe objective of this study was to examine the impact of microRNA-200c on embryo implantation and the expressions of alpha 5 beta 3, LIF, IL-6, CD105 (endogolin), and VEGF, which have a role in implantation. The experimental model comprised 30 female and 4 male rats. The rats were divided into two groups: the first group comprised non-pregnant rats, while the second group comprised pregnant rats. The pregnant rats were then separated into two groups: an experimental pregnant group and a control pregnant group. In the experimental group, rats were administered a microRNA200-c mimic solution (50 mu l of 0.9% sodium chloride) to the right uterine horn, while the left horn received an injection of 0.9% sodium chloride. The procedure was performed on day 3 of the pregnancy. The rats in the control group were not administered any treatment. On days 6 and 9 of gestation, the uteri were removed by cervical dislocation, after which the number of embryos was counted. The effects of alpha 5 beta 3, LIF, IL-6, CD105 (Endogolin), IL-6, CD105 (Endogolin) and VEGF proteins in the uterine tissues of the experimental pregnant groups were analysed using immunohistochemistry. MiRNA-200c reduced the number of implanted embryos by suppressing the expression of alpha 5 beta 3 integrin, LIF, IL-6, CD105 (endogolin), and VEGF. Based on these results, it can be concluded that mimic treatment may interfere with the process of implantation and early pregnancy by reducing the expression levels of in addition, integrin alpha 5 beta 3, LIF, IL-6, CD105 (Endogolin), VEGF.Article Validity and Reliability of the Turkish Version of the Fear of Cancer Scale(Sage Publications Ltd, 2025-04-04) Ozturk, Mehmet Halil; Kuday, Ahmet DoganThis study assessed the validity and reliability of the Turkish version of the Fear of Cancer Scale (FOCS) among 285 state university students from December 2022 to February 2023. The validity analysis included language, content, and structural assessments, with structural validity examined through exploratory and confirmatory factor analyses. Reliability was evaluated using item-total correlation, Cronbach's Alpha, and split-half analysis. Results confirmed that the Turkish version maintained the original factor structure, with a two-dimensional model explaining 52.73% of the variance. Factor loadings ranged from 0.455 to 0.757, and confirmatory factor analysis indicated acceptable model fit. The scale showed excellent internal consistency, with an overall Cronbach's Alpha of 0.920, and sub-dimension values of 0.870 for direct fear and 0.861 for indirect fear. These findings confirm the Turkish version of FOCS as a valid and reliable instrument for measuring cancer fear in non-oncological individuals.Article Citation - Scopus: 1The effect of wrist position sense and tactile recognition on manual skills in patients with upper extremity neuropathy(Hanley & Belfus-Elsevier Inc, 2025-07) Akman, Tuba Can; Gunes, Muge Icelli; Kitis, Ali; Erdogan, CagdasBackground: Peripheral neuropathy affects fine motor skills in daily life. However, reports on the effects of position sense and tactile recognition on manual dexterity are quite scarce in the literature. The increasing focus on hand rehabilitation has created a need to examine the effects of sensation on manual dexterity. Purpose: The purpose of this study is to compare the effect of tactile recognition and wrist position sense on manual skills in healthy and neuropathy individuals and to investigate the relationship between them. Study Design: Cross-sectional, non-randomized comparative clinical study. Methods: Thirty-seven (50 hands) with median and ulnar nerve neuropathy between the ages of 18 and 65 years and 32 (64 hands) healthy individuals of similar age and gender were included in the study. Wrist position sense was assessed using the K-FORCE Sens electrogoniometer as target angle, 30 degrees wrist flexion and extension, and 10 degrees radial and ulnar deviation. Shape-Texture Identification Test (STI), Purdue Pegboard test (PPT), and Michigan Hand Outcome Questionnaire were applied for tactile recognition, manual dexterity, and hand functions, respectively. The independent-sample t test and Mann-Whitney U test were used for K-FORCE Sens, STI, and PPT to compare groups. Correlation coefficient was used to determine the relationship between variables. Results: The mean age of individuals with neuropathy and healthy individuals was 45.7 +/- 10.3 and 44.5 +/- 9.2 years, respectively (p > 0.05). Seventy-three percent of individuals had median neuropathy and 27% had ulnar neuropathy. Totally, 33 dominant and 17 non-dominant hands of patients with neuropathy were affected. When healthy and neuropathic hands were compared, the mean error values in the dominant hand, flexion (4.4 +/- 1.4; 6.5 +/- 2.9), and radial deviation (2.4 +/- 1.0; 3.3 +/- 1.7) degrees were higher in the neuropathic hands (p < 0.05). Similar results were also found in the non-dominant hands. However, there was no difference between the mean error values in the extension and ulnar deviation degrees (p > 0.05). STI and PPT subtest results were also lower in the neuropathic hands (p < 0.05). There was a relationship between the mean error values of position sense in the flexion and radial deviation directions in the neuropathic dominant hands and all subtests of the PPT (p < 0.05), while there was a relation in the flexion direction in the non-dominant hand (p < 0.05). No relation was found in the Michigan Hand Outcome Questionnaire test (p > 0.05). Conclusions: This study has shown that in neuropathy rehabilitation, the assessment of position and tactile sensations should not be ignored in determining participation in manual skills. This article can be used as a starting point for further studies and can be considered as one of the sensory focal points in rehabilitation in the development of manual skills. (c) 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.Article Citation - WoS: 1Citation - Scopus: 1Psychometric evaluation of the Turkish version of the Work-Related Stress Scale: A study among search and rescue workers responding to the 2023 Kahramanmaraş earthquakes(Sage Publications Ltd, 2024-10-22) Ozturk, Mehmet Halil; Kuday, Ahmet DoganThis study evaluates the reliability and validity of the Turkish version of the Work-Related Stress Scale (WRSS) among search and rescue workers who responded to the 2023 Kahramanmara & scedil; earthquakes. Data were collected from 275 workers between January and April 2024 using the Personal Information Form and the Turkish version of the WRSS. Language, content, and construct validity were assessed, and reliability was determined using item-total correlation, Cronbach's alpha, split-half, and test-retest methods. The scale demonstrated strong content validity with a CVI range of 0.9-1.0 and a mean CVI of 0.98. Exploratory factor analysis yielded factor loadings from 0.469 to 0.932, resulting in four factors that explained 75.3% of the variance. The reliability coefficients for the sub-dimensions ranged from 0.833 to 0.900, with an overall Cronbach's alpha of 0.913. These results indicate that the Turkish WRSS is a valid and reliable tool for assessing stress among search and rescue workers.Article Citation - WoS: 3Citation - Scopus: 5Amelioration potential of synthetic oxime chemical cores against multiple sclerosis and Alzheimer's diseases: Evaluation in aspects of in silico and in vitro experiments(Elsevier B.V., 2024-12) Yilmaz, Anil; Koca, Murat; Ercan, Selami; Acar, Ozden Ozgun; Boga, Mehmet; Sen, Alaattin; Kurt, AdnanAlzheimer disease (AD) and multiple sclerosis (MS) are inflammatory neurological disorders. The main symptom of AD is dementia, and the main symptoms of MS are vertigo, sexual dysfunction, cognitive problems, and fatigue. Today, millions of people are affected by AD and MS, and the number is growing day by day. However, there are not any accurate remedies for both disorders. For this reason, discovering novel drug molecules against neurological disorders such as AD and MS is essential and precious. Oximes and benzofurans exhibit many pharmacological effects including anti-inflammatory and neurological activities. Thus, several novel compounds bearing oxime and benzofuran chemical cores were designed and synthesized, and their in vitro anticholinesterase activities were investigated in our previous study. A number of the synthesized molecules showed excellent anticholinesterase activity against both AChE and BChE enzymes. The mentioned study constituted a background for this study. In this study, we picked different chemical skeletons among all the synthesized molecules to conduct further in silico and in vitro experiments. In order to support our in vitro anticholinesterase findings, we also examined in silico anti-Alzheimer activity of the selected molecules. In addition, in silico and in vitro activities against MS disease of the synthesized molecules were investigated. Molecule 4 extraordinarily showed outstanding activity against AD disease both in silico and in vitro, as well as in silico activity against MS disease. This feature makes molecule 4 a possible drug lead molecule which is very limited in the market. On the other hand, molecule 1, a less substituted oxime skeleton, demonstrated the strongest in vitro activity against MS disease through in vitro anti-inflammatory effect. As an observation, molecule 4 was determined to be the most promising molecule to focus on in the further steps. © 2024 Elsevier B.V.Article Citation - WoS: 7Citation - Scopus: 6Lipid mixtures (from a liposome kit) and melatonin improve post-thawed Angora goat sperm parameters(Academic Press Inc., 2024-06) Bucak, Mustafa Numan; Karasor, Omer Faruk; Sari, Aysa; Bodu, Mustafa; Ili, Pinar; Narlicay, Salih; Ataman, Mehmet BozkurtSemen freezing and storing has been widely used in reproductive biotechnology, being applied to certain males of livestock breeds or animal species with economic value such as the Angora goat. The development of a semen extender with the cryoprotective agents can prevent the deterioration of sperm parameters after thawing. This study aimed to investigate lipid mixtures (from a liposome kit, Lps) and melatonin (Mel) at different doses to prevent the deterioration of sperm parameters and to provide the cryoprotective effects on sperm DNA. The Angora goat ejaculates were collected and pooled. They were divided into seven equal volumes, and each of them was diluted with the extenders of the experimental groups with additives (Lps 321.99 μg/mL, Lps 841.33 μg/mL, Mel 0.25 mM, Mel 1 mM, Lps 321.99 μg/mL + Mel 1 mM, Lps 841.33 μg/mL + Mel 0.25 mM) and no additives (control group). After the freeze-thawing process, motility, viability, acrosome integrity, DNA double-strand breaks, and abnormal DNA integrity were assessed for different extender groups. It was determined that the use of Lps alone at low dose or the combination of Lps and Mel had significant cryoprotective effects on motility, viability, acrosome integrity, and DNA damage in Angora goat sperm. This study will help us to understand the effects of Lps and Mel used alone or in combination at different doses and which doses give the optimum spermatological parameter rates following the freeze-thawing process, and hence it will shed light on further studies. © 2024 Society for CryobiologyArticle Citation - WoS: 10Citation - Scopus: 10The impact of heat treatment on the luminescence properties of Dy/Ag co-doped sodium alumina borate glasses(Elsevier Ltd, 2024-03) Kocyigit, Deniz; Gokce, Melis; Gokce, Aytac GuerhanThe sodium alumina borate glasses were synthesized by conventional melt-quenching method and heat treated with different durations to ensure the formation and growth of Ag nanoparticles. Transmission electron microscope measurements revealed that the average nanoparticle size increases with the heat treatment duration. The bonding nature between Dy3+ ions and surrounding ligands was getting more covalent with HT. Judd-Ofelt intensity parameters proved the asymmetric nature around Dy3+. The most intense emission and excitation bands of Dy3+ ions were observed for 6 h heat-treated glass (HT-6h). Intense blue (483 nm) and yellow (572 nm) emissions were obtained in which the yellow one has the highest radiative parameters approving the suitability of glasses for yellow laser applications. Based on colorimetric results emission closest to white light can be generated by HT-6h under 426 nm excitation. The decay time of 4F9/2 → 6H13/2 transition increases with heat treatment attributed to the combined effect of the enhanced local electric field induced by the Ag nanoparticles and energy transfer from Ag species to Dy3+ ions. The findings show that Dy3+/Ag+ co-doped sodium alumina borate glasses are potential materials for photonic applications. © 2024 Elsevier B.V.Article Citation - WoS: 7Citation - Scopus: 8Luminescence characteristics of Dy3+ doped sodium alumina borate glass: Role of silver(Iop Publishing Ltd, 2023-02-16) Kocyigit, Deniz; Gokce, Melis; Gokce, Aytac GürhanMetallic nanoparticle (NP) doped glasses have been studied as promising candidates for various technological applications due to their ability to improve the luminescence properties of rare earth ions. In this work, Dy2O3 and Ag2O co-doped sodium alumina borate glasses were synthesized by conventional melt-quenching technique. Raman analysis verified the existence of [BO3] and [BO4] groups with B-O stretching vibrations in the prepared glasses. Transmission electron microscope images confirmed the preŞence of spherical Ag NPs, whose average diameter is about 7.60 nm, in H-0.5Dy1Ag glass matrix. The optical and luminescence properties were investigated according to Ag concentrations. The negative value of the bonding parameters, calculated from the absorption spectra, indicates the ionic nature between the Dy3+ ions and its surrounding ligands. In order to determine the nature of the Dy-O bond and the symmetry around the Dy3+ ion environment, Judd-Ofelt intensity parameters (omega (lambda), lambda = 2, 4, 6) were obtained from the absorption spectra. The luminescence spectra obtained under 350 nm excitation exhibits four emission bands at 481 (F-4(9/2)-> H-6(15/2)), 572 (F-4(9/2)-> H-6(13/2)), 662 (F-4(9/2)-> H-6(11/2)), and 750 (F-4(9/2)-> H-6(9/2)) nm. The intensity of emission spectra increases with Ag2O content until 1.0 wt% in H-0.5Dy-yAg glasses and then decreases due to the back-energy transfer (ET) from Dy3+ to Ag+. The ET mechanism from Ag+ to Dy3+ ion for H-1Ag-xDy glasses were investigated through Forster-Dexter's theory and were found to be quadrupole-quadrupole type. The various radiative properties were calculated by using Judd-Ofelt intensity parameters and emission spectra. It was found that the 572 nm emission band, located in the yellow region, has higher radiative parameters. As a function of Ag concentration, the Y/B values, Commission Internationale d'Eclairage (CIE) chromaticity coordinates (x,y) and correlated color temperatures (CCT) were evaluated. The CIE chromaticity coordinates and CCT values of all glasses are located in the white light region. The decay time values of S-1(0)-> D-3(1) transition of Ag+ ions and F-4(9/2)-> H-6(13/2) transition of Dy3+ ions confirm the ET from Ag+ to Dy3+ ions. Overall, the preŞent study indicates that the synthesized glasses with Ag addition exhibits improved luminescence, mAkıng them potential candidate for white LEDs.
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