Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/46898
Title: Egg yolk oil accelerates wound healing in streptozotocin induced diabetic rats
Authors: Ili, Pinar
Sari, Fikret
Keywords: Basal membrane
collagen fiber
diabetes
egg yolk oil
elastic fiber
growth factor
histochemistry
immunohistochemistry
mast cell
rats
wound healing
Epidermal-Growth-Factor
Mast-Cell
Basement-Membrane
Double-Blind
Risk-Factors
Foot Ulcers
Skin Wounds
Angiogenesis
Expression
Extract
Publisher: Taylor & Francis Ltd
Abstract: Impaired diabetic wound healing causes foot ulcers. We investigated egg yolk oil for skin wound healing in streptozotocin (STZ) induced diabetic rats. Rats were allocated into three groups of six. Group 1, nondiabetic control group, was treated topically with 2% fusidic acid ointment. Group 2, STZ diabetic control, was treated topically with 2% fusidic acid ointment. Group 3, STZ diabetic group, was treated topically with egg yolk oil. Three days after STZ injection, two full thickness excisional skin wounds were created on the back of each animal. Wound diameter was measured for 14 days and wound contraction was calculated. Re-epithelization time also was determined. Three rats from each group were sacrificed on experimental day 7 and the remaining rats on day 14. Wound samples were examined using hematoxylin and eosin, periodic acid-Schiff, Masson's trichrome, Taenzer-Unna orcein and toluidine blue staining. Expression of endoglin (CD105), epidermal growth factor (EGF) and vascular endothelial growth factor (VEGF) were investigated using immunohistochemistry. Egg yolk oil increased the proliferation of epithelial cells and angiogenesis, and stimulated collagen deposition in the lesion area. Egg yolk oil increased CD105, EGF and VEGF expression in blood vessels, and EGF and VEGF expression in epidermis of the lesions. The predominant fatty acids in egg yolk oil are oleic, palmitic and linoleic, which likely were responsible for the beneficial effects of egg yolk oil on diabetic wound healing. Egg yolk oil appears to be a promising therapeutic agent for healing of diabetic wounds.
URI: https://doi.org/10.1080/10520295.2022.2115554
https://hdl.handle.net/11499/46898
ISSN: 1052-0295
1473-7760
Appears in Collections:Denizli Sağlık Hizmetleri Meslek Yüksekokulu Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tavas Meslek Yüksekokulu Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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