Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/47475
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dc.contributor.authorBaygu Y.-
dc.contributor.authorKabay N.-
dc.contributor.authorKabay B.-
dc.contributor.authorYıldız B.-
dc.contributor.authorÖmeroğlu İ.-
dc.contributor.authorDurmuş M.-
dc.contributor.authorRıza Karagür E.-
dc.contributor.authorAkca, Hakan-
dc.contributor.authorErgin, Cagri-
dc.contributor.authorGok, Yasar-
dc.date.accessioned2023-01-09T21:24:53Z-
dc.date.available2023-01-09T21:24:53Z-
dc.date.issued2023-
dc.identifier.issn0022-2860-
dc.identifier.urihttps://doi.org/10.1016/j.molstruc.2022.134010-
dc.identifier.urihttps://hdl.handle.net/11499/47475-
dc.description.abstractIn this study, a novel peripheral zinc(II) phthalocyanine (ZnPc) containing cyclic two triazole moieties which include 24 or 26-membered macrocyclic zinc(II) phthalocyanine was synthesized via multistep reactions. The precursor macrocyclic phthalonitrile was converted into the related phthalocyanine by cyclotetramerization reaction. The photochemical, in-silico selective targeting of cancer related genes and in vitro antiproliferative effect of this zinc(II) phthalocyanine was investigated. Singlet oxygen production properties of the synthesized phthalocyanine compound (ZnPc) indicated as singlet oxygen quantum yield (?? = 0.47). In- silico studies proved the efficient and specific binding capability of G-quadruplex nucleic acids. ZnPc compound demonstrated antiproliferative effect in vitro on human non-small cell lung carcinoma cell lines. © 2022en_US
dc.description.sponsorshipTürkiye Bilimsel ve Teknolojik Araştırma Kurumu, TÜBİTAK: 114Z441en_US
dc.description.sponsorshipAuthors are thankful to The Scientific and Technological Council of Turkey (Ankara-Turkey) for financial support (Project No: 114Z441 ).en_US
dc.language.isoenen_US
dc.publisherElsevier B.V.en_US
dc.relation.ispartofJournal of Molecular Structureen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectClick reactionen_US
dc.subjectMacrocyclizationen_US
dc.subjectMolecular docking, in vitroen_US
dc.subjectSinglet oxygenen_US
dc.subjectZn(II)phthalocyanineen_US
dc.subjectCell cultureen_US
dc.subjectMolecular oxygenen_US
dc.subjectZinc compoundsen_US
dc.subjectClick reactionen_US
dc.subjectIn-vitroen_US
dc.subjectMacro-cyclizationen_US
dc.subjectMacrocyclicsen_US
dc.subjectMolecular dockingen_US
dc.subjectMolecular docking, in vitroen_US
dc.subjectPhotochemicalsen_US
dc.subjectSinglet oxygenen_US
dc.subjectSynthesiseden_US
dc.subjectZn(II)phthalocyanineen_US
dc.subjectNucleic acidsen_US
dc.titleSynthesis, characterization and investigation of photochemical and in vitro antiproliferative properties of novel Zn(II) phthalocyanineen_US
dc.typeArticleen_US
dc.identifier.volume1271en_US
dc.identifier.doi10.1016/j.molstruc.2022.134010-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.authorscopusid55388209500-
dc.authorscopusid9251050200-
dc.authorscopusid6507051961-
dc.authorscopusid57190139734-
dc.authorscopusid55897062400-
dc.authorscopusid57869859100-
dc.authorscopusid55968558200-
dc.identifier.scopus2-s2.0-85137102003en_US
dc.identifier.wosWOS:000859282600012en_US
dc.identifier.scopusqualityQ2-
item.fulltextNo Fulltext-
item.languageiso639-1en-
item.openairetypeArticle-
item.cerifentitytypePublications-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.dept38.02. Reservation of Ownership and Security-
crisitem.author.dept20.03. Biomedical Engineering-
crisitem.author.dept14.01. Surgical Medicine-
crisitem.author.dept14.02. Internal Medicine-
crisitem.author.dept14.03. Basic Medical Sciences-
crisitem.author.dept17.01. Chemistry-
Appears in Collections:Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tavas Meslek Yüksekokulu Koleksiyonu
Teknoloji Fakültesi Koleksiyonu
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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