Tıp Fakültesi Koleksiyonu
Permanent URI for this collectionhttps://hdl.handle.net/11499/46004
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Article Evaluating the Efficacy and Safety of Carotid Artery Stenting: A Retrospective Analysis(Galenos Publ House, 2025-12-18) Civlan, Serkan; Erbek, Nevzat Dogukan; Tekin, Isik; Arslan, Muhammet; Keskin, Emrah; Asar, Rasim; Peker, Hakki; Yakar, FatihObjective Stroke is the second leading cause of death and the third leading cause of disability globally, with carotid artery stenosis contributing to approximately 20% of cases. Carotid artery stenting (CAS) and carotid endarterectomy (CEA) are effective treatments to reduce stroke risk. While some studies report higher complication rates for CAS compared to CEA, others demonstrate comparable outcomes, emphasizing the importance of patient selection and procedural optimization. This study evaluates the real-world safety and effectiveness of CAS in 52 patients at a single institution. Methods This retrospective analysis included 52 patients who underwent CAS between 2020 and 2024. Inclusion criteria were >= 50% stenosis for symptomatic patients and >60% stenosis for asymptomatic ones. Dual antiplatelet therapy was initiated preoperatively, and distal filter embolic protection was used in all procedures. Neurological assessments and radiological imaging were performed pre- and post-procedure. Complications were categorized as periprocedural or post-procedural, and follow-ups were conducted at three, six, and twelve months. Results The cohort included 52 patients (78.8% symptomatic, mean stenosis rate: 80.3%+/- 12.5%). Periprocedural ischemic stroke occurred in 5.8% of patients, and asymptomatic diffusion-restricted areas were detected in 34.6% of patients. One patient (2.2%) experienced symptomatic intracerebral hemorrhage. The overall periprocedural stroke and death rate was 7.7%. Conclusion CAS is a minimally invasive, effective option for treating carotid artery stenosis when patient selection and procedural protocols are optimized. Ongoing advancements in techniques and devices are anticipated to reduce complications further, supporting CAS as a safe alternative to CEA in selected patients.Article Bibliometric and Visual Analysis of the Top 100 Most Cited Articles on Long-Acting Injectable Antipsychotics(Kare Publ, 2025) Tekin, Selin Balki; Aygun, Danis; Kenar, Ayse Nur InciObjective: Recently, there has been a notable increase in interest in long-acting injectable antipsychotics (LAIAs) and in the number of studies conducted in psychopharmacology. This study aims to identify and analyze the 100 most cited articles on LAIAs. Method: The Web of Science (WOS) Core Collection database was analyzed using VOSviewer software to identify published articles on the subject. Information such as titles, authors, journals and publishers, number of citations, and years of publication was examined. The publications were then ranked according to the number of citations, and the top 100 most cited articles were subjected to further analysis. Results: The total number of citations ranged from 65 to 1,044. The most cited article is the 'International Consensus Study of Antipsychotic Dosing' in 2010, published in The American Journal of Psychiatry, with 1,044 citations. The Journal of Clinical Psychiatry contributed the greatest number of articles to the top 100 most cited articles, with 20 articles, followed by The British Journal of Psychiatry and Schizophrenia Research, which contributed eight and seven articles, respectively. The oldest publication in the top 100 was published in 1998, and the two most recent articles were published in 2022. Conclusion: This analysis allows researchers and clinicians to gain insight into the most recent and impactful work in this field, particularly in identifying potential avenues for future academic research.Article A Bibliometric Review of Residency Theses on Vertigo in Türkiye(Galenos Publishing House, 2025-11-04) Aydemir, Gokce; Kara, Cuneyt Orhan; Ardic, Fazil NecdetObjective: In our study we analyzed the residency theses on vertigo in Türkiye by year, subject, and specialty with the aim of identifying academic trends. Methods: A bibliometric review was conducted using the National Thesis Database (1972-2025). The search was performed with the keywords vertigo, vestibular, dizziness, and Ménière. Only medical specialization theses were included. Titles and abstracts were screened, and eligible theses were classified by year, specialty, and topic. Results: A total of 180 theses were identified. The highest number of theses was produced between 2016 and 2020, followed by a decline after 2021. In the study period 103 theses were published in otorhinolaryngology, 29 in neurology, 10 in physical medicine and rehabilitation, 23 in emergency and family medicine, and 15 in other specialties. While studies showed an apparent increase in vestibular testing and rehabilitation in recent decades, these emphasized etiology and diagnostic approaches in the earlier years. Conclusion: Most theses on vertigo were produced between 2016 and 2020, with otorhinolaryngology providing the most significant contribution. Over time, interest shifted from etiology and diagnosis towards vestibular testing and rehabilitation. The findings confirm that vertigo is a central subject in otorhinolaryngology, but also attracts growing attention in neurology, physical medicine and rehabilitation, emergency medicine, and family medicine.Article Impact of Patulin on Apoptosis, Autophagy, and Tumor Growth in Human Malignant Mesothelioma and Normal Mesothelial Cells(Biomedpress, 2025-11-30) Akkutlu, Rumeysa; Yuce, Hande; Ozek, Dilan Askin; Berberoglu, Yasemin; Unuvar, SongulPatulin (PAT) is a mycotoxin produced by certain molds, particularly species of the genera Aspergillus and Penicillium. It is found predominantly in apple-derived products and is associated with both acute and chronic toxicities. Although comprehensive data on the anti-cancer properties of PAT are presently lacking, preliminary evidence suggests that it can influence cancer cells by enhancing cellular apoptosis and inducing cytotoxicity. To evaluate the potential of PAT as a therapeutic approach for malignant mesothelioma, we investigated its effects on the malignant mesothelioma cell line H2452 and the non-malignant mesothelial cell line MeT-5A. Cells were exposed to PAT (1-200 mu M). Cell viability was assessed using the MTS assay, and cell migration was evaluated using the wound-healing assay. Expression levels of genes related to autophagy and apoptosis (SQSTM1, Beclin-1, Atg5, Atg7, Bax, Bcl-2) were measured using RT-PCR. PAT produced a dose-dependent decrease in cell viability and exhibited greater cytotoxicity toward mesothelioma cells than toward healthy cells. The wound-healing assay demonstrated that PAT impeded cellular migration, as evidenced by dysregulated wound closure. In cancer cells, PAT down-regulated Bax, Bcl-2, Beclin-1, and SQSTM1, while up-regulating Atg5 and Atg7. In healthy cells, it reduced Bax, Bcl-2, Beclin-1, SQSTM1, and Atg7, and elevated Atg5. It increased apoptosis in both healthy and cancer cells while modulating autophagy pathways in both cell types, potentially attenuating autophagy in cancer cells and disrupting this process in healthy cells. Our findings indicate that PAT may significantly restrict tumor progression in human mesothelial cancer models.Article Differential Myokine Responses To Swimming: Highlighting Meteorin-Like (Metrnl) as a Unique Marker of Adaptation(Istanbul Univ, 2025-12-09) Oskay, Alten; Erkek, Ozgen Kilic; Senol, Hande; Ozen, Mert; Unal, Egem Burcu; Kucukatay, Melek BorObjective: We examined time-dependent changes in the levels of meteorin-like protein (Metrnl), interleukin (IL)-7, IL-8, and follistatin-like 1 (FSTL1) myokines in mouse gastrocnemius-soleus tissue and plasma samples following acute and long-term swimming exercises. Materials and Methods: Seventy 8-12 weeks-old adult male BALB/c mice were classified as control (sedentary) and exercise groups. Either an acute or chronic exercise regime was applied to the exercise group. Samples were collected at 0 h, 3 h, and 48 h. The acute exercise group completed a 30-min single swimming session. The chronic exercise group completed the 30-min swimming exercise every day, 5 days a week, for 6 weeks. Metrnl, IL-7, IL-8, and FSTL1 levels in the m. gastrocnemius-soleus muscle and plasma samples were determined by enzyme-linked immunosorbent method (ELISA) kits. Results: No changes were observed in the Metrnl, IL-7, IL-8, and FSTL1 levels in the gastrocnemius-soleus muscle complex following acute or 6 weeks of swimming exercise (p>0.05). IL-7, IL-8, and FSTL1 levels did not change in the plasma in response to the exercises (p>0.05). Plasma Metrnl levels were higher at 3 h after 6 weeks of chronic exercise compared with the control (sedentary) and the 3 h samples of the acute swimming (3.49 +/- 1.75 ng/mL, 1.75 +/- 0.48 ng/mL, and 1.66 +/- 0.33 ng/mL; p<0.001, respectively) groups. Conclusion: These findings suggest that unlike IL-7, FSTL1, and IL-8, only Metrnl may playa role in mediating adaptation to long-term exercise in mice.Article Investigation of the Effects of Nepeta Italica Subsp. Cadmea Extract on Frozen-Thawed Ankara Buck Spermatozoa(Hellenic Veterinary Medical Soc, 2025-11-05) Boztas, S.; Keskin, N.; Bucak, M. N.; Urganci, B. Er; Bodu, M.; Taspinar, F.Semen cryopreservation causes adverse effects on the sperm structure especially on plasmalem-ma, acrosomes and DNA which results in lowered fertilization capacity. Hereby, cryoprotective antioxidant molecules have been extensively investigated to overcome the deleterious effects of oxidative stress caused by cryopreservation in spermatozoa. In recent years, natural antioxidants rich in flavonoids and phenolic compounds have gained increasing attention to develop as novel cryoprotectants in spermatozoa cryopreservation. Nepeta italica subsp. cadmea (Boiss.) rich in terpenoids and flavonoids is endemic to Turkey. In this study, the effects of three different doses of Nepeta italica subsp. cadmea extract (0.75 mu L/10 mL, 1.5 mu L/10 mL and 6 mu L/10 mL) on motility, acrosome integrity, mitochondrial activity and DNA fragmentation in frozen-thawed Ankara buck spermatozoa were investigated. The plants were harvested during the flowering stage on Honaz Mountain (Denizli, Turkey) and air dried in the shade at room temperature. The extract of the powdered plant was extracted by hydrodistillation using a Clevenger apparatus system, then stored at 4 degrees C in an amber colored glass bottle. The ejaculates taken from the Ankara bucks during the breeding season with an electroejaculator were combined and used in the diluting and freezing of semen. The experomental groups were formed by adding three different doses of Nepeta italica subsp. cadmea extract (0.75 mu L/10 mL, 1.5 mu L/10 mL and 6 mu L/10 mL) to the control extender. The semen was diluted with the different extenders at 35-37 degrees C and loaded into straws. Sperm samples frozen in liquid nitrogen vapors, following equilibration, were stored in liquid nitrogen. The plant extract at the dose of 0.75 mu L/10 mL improved motility, acrosome integrity, mitochondrial activity and DNA fragmentation in post-thawed Ankara buck spermatozoa (p<0.05). As a result, it can be suggested that the most effective dose of 0.75 <mu>L/10 mL of Nepeta italica subsp. cadmea (Boiss.) extract can be used as an effective additive for freezing Ankara buck spermatozoa.Article Evaluation of End-Expiratory Lung Volume, Gain and Pulmonary Mechanics with Peep Titration in Mechanical Ventilation of Intensive Care Unit Patients(Bayrakol Medical Publisher, 2025) Kuvandik, Anil; Tanriverdi, Selvinaz Yuksel; Sargin, Fatih; Sungurtekin, HulyaAim: Mechanical ventilation is an integral part of intensive care treatment. A wide variety of parameters have been investigated until today in order to direct mechanical ventilation in intensive care units. In patients who are controlled ventilated by mechanical ventilator; individualized optimal selection of positive end-expiratory pressure (PEEP) is important to protect the lung from ventilation-related trauma, to gain atelectatic areas and to prevent the closing of ventilated lung areas. Materials and Methods: In this study, 20 patients followed up with a mechanical ventilator in the intensive care unit of a university were included. In our study, Functional residual capacity (FRC), end-expiratory lung volume (EELV), gain and respiratory mechanics were investigated with increased PEEP titration procedure in patients undergoing controlled mechanical ventilation in the intensive care unit. FRC and EELV were measured by the multiple breath nitrogen wash out technique. Gain and compliance evaluations were made on the dynamic pressure-volume curves created with the intratracheal pressure sensor. Result: It was observed that FRC, EELV, the volume change measurements on dynamic pressure-volume curves and gain measurements are easily applicable at the bedside. Optimal PEEP values; 5 +/- 3.62 cmH2O for static compliance, 4.75 +/- 3.79 cmH2O for elastance, 4.75 +/- 3.43 cmH2O for driving pressure. The optimal PEEP according to the gain was determined as 11.75 +/- 3.35 cmH2O. EELV reached the predicted FRC values at an average PEEP level of 4.06 +/- 5.83 cmH2O. Discussion: It was found that the gain did not significantly correlate with compliance, elastance, and driving pressure and was not sensitive to lung distension.Article Subclinical Spondyloarthritis Features in Patients with Hidradenitis Suppurativa: A Real-World Cross-Sectional Analysis(Erciyes University School of Medicine, 2025) Bakay, Umut; Bakay, Ozge Sevil KarstarliObjective: The objective of this study is to investigate the frequency and clinical spectrum of subclinical spondyloarthritis (SpA) manifestations among patients with hidradenitis suppurativa (HS) and to evaluate their association with cutaneous disease severity and clinical characteristics. Materials and Methods: In this prospective, cross-sectional real-world study, 120 adults with a confirmed diagnosis of HS were systematically assessed for musculoskeletal involvement. The evaluation included clinical examination for inflammatory back pain, peripheral arthritis, enthesitis, and targeted magnetic resonance imaging (MRI) forsacroiliitis when indicated. Laboratory analyses included C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and human leukocyte antigen B27 (HLA-B27) status. Spearman's rank correlation was used to analyze relationships between SpA-related features and HS clinical parameters, including the International Hidradenitis Suppurativa Severity Score System (IHS4) score, Hurley stage, and smoking. Results: Among the cohort, MRI-confirmed sacroiliitis was detected in 13.3%, enthesitis in 18.3%, HLA-B27 positivity in 12.5%, and peripheral arthritis in 10.0% of patients. A total of 12.5% fulfilled the modified New York criteria for ankylosing spondylitis. No statistically significant correlations were observed between SpA findings and HS severity indices. Weak associations were noted between smoking and both HLA-B27 positivity (rho=0.27) and peripheral arthritis (rho=0.21). Conclusion: Subclinical axial and peripheral SpA features are frequently encountered in patients with HS, often in the absence of musculoskeletal complaints. The lack of correlation with skin disease activity highlights the need for routine rheumatologic evaluation in this population to enable early recognition and tailored treatment of inflammatory joint disease.Article Enhancing Effect of Bevacizumab in the Classic Bleomycin, Etoposide, Cisplatin Treatment Applied in Human Testicular Germ Cell Tumors(Cukurova University, Faculty Medicine, 2025-09-30) Koc, Deniz; Tosun, Murat; Unal, Murat SerkantPurpose: This study aimed to evaluate the therapeutic potential of Bevacizumab, a vascular endothelial growth factor (VEGF) inhibitor, in combination with the standard Bleomycin, Etoposide, and Cisplatin (BEP) regimen for the treatment of testicular germ cell tumors (TGCTs). The primary focus was to investigate its ability to enhance treatment efficacy while reducing cytotoxic side effects. Materials and Methods: The half-maximal inhibitory concentration (IC50) of the BEP regimen was determined in the 1618-K human TGCT cell line and subsequently combined with varying concentrations of Bevacizumab. Cell viability was assessed using the 3-(4,5-dimethylthiazolwere analyzed by immunohistochemistry. Results: Bevacizumab significantly reduced cell viability in (2.05 +/- 1.04) was significantly lower than in the control mechanisms. through in vivo studies.Article Comparative Analysis of COMT Expression Levels in Blood and Exosomederived Samples of Patients with Schizophrenia(Cukurova University, Faculty Medicine, 2025-09-30) Altintas, Nuray; Ciddi, Sebnem; Bulut, Demet; Tonk, Onur; Yilmaz, Ozge Sarica; Tokgun, Pervin Elvan; Gul, Cihan; Esen-danaci, AysenPurpose: The objective of this study was to analyse the variability of COMT expression in peripheral blood and exosome samples from individuals diagnosed with schizophrenia and to establish its correlation with the drugs employed in the treatment of schizophrenia. Materials and Methods: 45 subjects diagnosed with chronic schizophrenia were included in the patient group and 45 healthy volunteers with no family history of chronic schizophrenia were included in the control group. RNA isolation from exosome and peripheral blood was performed for each individual in the sample group. Realtime polymerase chain reaction was used to determine COMT expression levels obtained from peripheral blood and exosome samples and their association with drugs used in antipsychotic therapy was evaluated. Results: Differential gene expression analysis was performed using the 2-Delta Delta CT method. The analysis revealed an increase in COMT gene expression levels in exosome samples. Similarly, an increase in COMT expression levels was detected in peripheral blood samples. In peripheral blood samples, 31 patients exhibited an increase and 14 patients exhibited a decrease. In the exosome samples, a decrease in COMT gene expression was observed in 25 subjects, while an increase was observed in 20 subjects. A statistically significant difference was found between COMT expression levels in peripheral blood and exosome samples. Conclusion: Investigation of alterations in COMT expression levels in schizophrenia and its treatment may provide a valuable framework for future studies to elucidate the mechanisms of this psychiatric disorder.